CAJ | 학술논문

目的：观察中药稳消方对颈动脉粥样硬化(CAS)斑块形成患者血液流变学的影响。方法将60例 CAS斑块形成患者随机分为干预组(33例)及对照组(27例)。干预组加稳消方治疗，并进一步分为干预半年组与对照半年组、干预1年组与对照1年组，分别比较患者血液流变学变化情况。结果与本组治疗前比较，干预1年组在全血黏度(高、中、低切)、血浆黏度、全血低切还原黏度方面降低达到统计学意义(P<0.05或P<0.01)；且与对照1年组治疗后比较，血黏度指标亦可见明显降低，但尚未达到统计学意义(P>0.05)。结论随干预时间延长，稳消方可改善CAS斑块形成患者血液流变学指标，用药安全性良好。
목적：관찰중약은소방대경동맥죽양경화(CAS)반괴형성환자혈액류변학적영향。방법장60례 CAS반괴형성환자수궤분위간예조(33례)급대조조(27례)。간예조가은소방치료，병진일보분위간예반년조여대조반년조、간예1년조여대조1년조，분별비교환자혈액류변학변화정황。결과여본조치료전비교，간예1년조재전혈점도(고、중、저절)、혈장점도、전혈저절환원점도방면강저체도통계학의의(P<0.05혹P<0.01)；차여대조1년조치료후비교，혈점도지표역가견명현강저，단상미체도통계학의의(P>0.05)。결론수간예시간연장，은소방가개선CAS반괴형성환자혈액류변학지표，용약안전성량호。
Objective To observe the effect of Wenxiao decoction on hemorheology in treating the patients with carotid atheroscle-rostic(CAS)plaque.Methods Sixty patients with CAS plaque were randomly allocated to two groups,33 patients in treatment group who were treated with Wenxiao Decoction and 27 patients in control group.They were further divided into 0.5 year treatment group and 0.5 year control group,1 year treatment group and 1 year control group.Before and after treatment,hemorheology of all pa-tients were examined.Results After therapy,the whole blood viscosity (high,medium and low shear),plasma viscosity and low shear whole blood reductive viscosity of 1 year treatment group were decreased(P<0.05 or P<0.01).And Compared with the 1 year control group after therapy,the parameters of hemorheology were also decreased obviously,but had no statistical difference(P>0.05). Conclusion With elongation of treatment time,Wenxiao Decoction could improve the hemorheology of patients with CAS plaque and it voas safe during treatment.