CAJ | 학술논문

目的：探讨不同剂量瑞舒伐他汀对急性冠脉综合征患者血清血管细胞黏附分子1(VCAM 1)、细胞间黏附分子1(ICAM 1)和纤溶酶原激活物抑制剂1(PAI 1)水平的影响。方法将急性冠脉综合征患者256例随机分成 A 组(瑞舒伐他汀10 mg/d,128例),B组(瑞舒伐他汀20 mg/d,128例),另选50例冠状动脉造影检查证实无冠状动脉狭窄者设为对照组。分别于治疗前及治疗后1周、2周收集血液,采用酶联免疫吸附剂法测定血清 VCAM 1、ICAM 1和PAI 1浓度。结果急性冠脉综合征患者血清中 VCAM 1、ICAM 1和PAI 1的水平明显高于正常对照组(P<0.05)；A 组、B 组在治疗后1周、2周 VCAW 1、ICAM 1和PAI 1的水平较治疗前降低(P<0.05)；B组在治疗后 VCAW 1、ICAM 1和 PAI 1水平均较 A组低(P<0.05)。结论瑞舒伐他汀可以有效降低 ACS患者血清中 VCAM 1、ICAM 1和PAI 1的水平,且随着瑞舒伐他汀剂量的增加,其降低ACS患者血清 VCAM 1、ICAM 1和PAI 1水平的作用更为显著。
목적：탐토불동제량서서벌타정대급성관맥종합정환자혈청혈관세포점부분자1(VCAM 1)、세포간점부분자1(ICAM 1)화섬용매원격활물억제제1(PAI 1)수평적영향。방법장급성관맥종합정환자256례수궤분성 A 조(서서벌타정10 mg/d,128례),B조(서서벌타정20 mg/d,128례),령선50례관상동맥조영검사증실무관상동맥협착자설위대조조。분별우치료전급치료후1주、2주수집혈액,채용매련면역흡부제법측정혈청 VCAM 1、ICAM 1화PAI 1농도。결과급성관맥종합정환자혈청중 VCAM 1、ICAM 1화PAI 1적수평명현고우정상대조조(P<0.05)；A 조、B 조재치료후1주、2주 VCAW 1、ICAM 1화PAI 1적수평교치료전강저(P<0.05)；B조재치료후 VCAW 1、ICAM 1화 PAI 1수평균교 A조저(P<0.05)。결론서서벌타정가이유효강저 ACS환자혈청중 VCAM 1、ICAM 1화PAI 1적수평,차수착서서벌타정제량적증가,기강저ACS환자혈청 VCAM 1、ICAM 1화PAI 1수평적작용경위현저。
Objective To explorer the effect of different doses of rosuvastatin on serum concentrations of vascular cell adhesion molecule l (VCAM 1),intercellular adhesion molecule 1(ICAM 1),and plasminogen activator inhibitor 1 (PAI 1)in the pa-tients with acute coronary syndrome (ACS).Methods A total of 236 patients with acute coronary syndrome were randomly divided into A group (128 patients were administrated to rosuvastain 10 mg per day)and B group (128 patients were administrated to rosuv-astain 20 mg per day).Another 50 age matched healthy subjects who were confirmed no coronary artery stenosis by coronary angi-ography were enrolled as control group.Serum samples of the patients in both A and B group were collected in order to detect the level of VCAM 1,ICAM 1,and PAI 1 before the patients accept rosuvastain and 1 and 2 weeks after the treatment.The level of VCAM 1, ICAM 1 ,and PAI 1 were measured by Enzyme Linked Immunosorbent Assay.Results Compared with the control group,the con-centrations of serum VCAM 1,ICAM 1,and PAI 1 were significantly increased in patients with ACS (P<0.05).After 1 and 2 weeks of the treatment,the concentrations of serum VCAM 1,ICAM 1,PAI 1 were decreased both in A and B group (P<0.05). Whereas in the B group,the concentrations of serum VCAM 1 ,ICAM 1 ,and PAI 1 were lower than that in the A group both 1 and 2 weeks after the treatment (P<0.05).Conclusion Significant decreases of VCAM 1,ICAM 1 and PAI 1 in ACS patients were observed at both 1 and 2 weeks after treatment with rosuvastatin,and significantly greater reduction were observed with the in-creasing dose of rosuvastatin.