CAJ | 학술논문

目的：研究高血压病患者血清白介素6(IL 6)与心脑血管梗死事件及中医证候的相关性。方法收集226例高血压病患者的临床资料,采用酶联免疫吸附法检测患者的血清 IL 6浓度,分析 IL 6与心脑血管梗死事件及中医证候的相关性。结果相关分析显示,高血压病患者的血清 IL 6浓度与并发心脑血管梗死事件呈显著正相关(P<0.01)。痰证患者的血清 IL 6浓度[中位数(四分位数间距)]显著高于非痰证患者[30.56(99.40)pg/mL vs 3.03(99.87)pg/mL,(P<0.01)],并且 IL 6与痰证的出现呈正相关关系(r=0.371,P<0.01)。结论 IL 6对评估高血压病患者并发心脑血管梗死事件的风险和辅助中医痰证的辨证具有一定参考价值。
목적：연구고혈압병환자혈청백개소6(IL 6)여심뇌혈관경사사건급중의증후적상관성。방법수집226례고혈압병환자적림상자료,채용매련면역흡부법검측환자적혈청 IL 6농도,분석 IL 6여심뇌혈관경사사건급중의증후적상관성。결과상관분석현시,고혈압병환자적혈청 IL 6농도여병발심뇌혈관경사사건정현저정상관(P<0.01)。담증환자적혈청 IL 6농도[중위수(사분위수간거)]현저고우비담증환자[30.56(99.40)pg/mL vs 3.03(99.87)pg/mL,(P<0.01)],병차 IL 6여담증적출현정정상관관계(r=0.371,P<0.01)。결론 IL 6대평고고혈압병환자병발심뇌혈관경사사건적풍험화보조중의담증적변증구유일정삼고개치。
Objective To study the correlation between interleukin 6 (IL 6),cardiovascular and cerebrovascular infarction events, and traditional Chinese medicine (TCM)syndrome in patients with hypertension.Methods Clinical data of 226 patients with essential hypertension were collected.The serum concentration of IL 6 was detected by ELISA.Then the correlation between IL 6,infarction events and TCM syndromes were analyzed.Results The analysis showed that cardiovascular and cerebrovascular infarction events was positively correlated with the serum concentration of IL 6 (P<0.01).Compared with non phlegm syndrome group,the serum concentration of IL 6 was increased significantly in phlegm syndrome group (P<0.01).Furthermore,there was a positive correla-tion between IL 6 and phlegm syndrome (P<0.01).Conclusion IL 6 had some reference value to evaluate the risk of the cardio-vascular and cerebrovascular events and to assist TCM differentiation of phlegm syndrome in patients with hypertension.