CAJ | 학술논문

目的：探讨超声对分别首次服用奥氮平和阿立哌唑的精神分裂症患者胃排空功能的影响。方法40例精神分裂症首次发病患者随机服用奥氮平和阿立哌唑各20例，用实时二维B超胃窦单切面法测量治疗前及治疗4周后空腹胃窦面积（S空腹）、胃排空时间（T）、胃窦收缩频率（F）、胃窦收缩幅度（△S），观察药物对各项胃动力指标的影响。结果奥氮平组治疗前胃排空时间为57.04±9.86min，治疗后为52.35±9.86min，经药物治疗后，奥氮平组较治疗前胃排空时间变短。奥氮平组治疗前胃窦收缩幅度、收缩频率分别为2.09±0.59cm2和2.72±0.35次/分，治疗后分别为2.60±0.73cm2和2.98±0.70次/分，较治疗前胃窦收缩幅度增大、收缩频率加快。阿立哌唑组治疗前胃排空时间为62.69±12.09min，治疗后为64.81±12.16min，胃窦收缩幅度、收缩频率分别为2.68±0.83cm2和3±0.90次/分，治疗后分别为2.62±0.73cm2和2.75±0.86次/分，阿立哌唑组治疗前后各项指标变化无明显差异。结论奥氮平组精神分裂症患者胃排空加快，胃窦收缩幅度增大、收缩频率加快，胃动力改变时患者体重增加的发病机制之一，阿立哌唑组患者胃排空功能无明显变化。
목적：탐토초성대분별수차복용오담평화아립고서적정신분렬증환자위배공공능적영향。방법40례정신분렬증수차발병환자수궤복용오담평화아립고서각20례，용실시이유B초위두단절면법측량치료전급치료4주후공복위두면적（S공복）、위배공시간（T）、위두수축빈솔（F）、위두수축폭도（△S），관찰약물대각항위동력지표적영향。결과오담평조치료전위배공시간위57.04±9.86min，치료후위52.35±9.86min，경약물치료후，오담평조교치료전위배공시간변단。오담평조치료전위두수축폭도、수축빈솔분별위2.09±0.59cm2화2.72±0.35차/분，치료후분별위2.60±0.73cm2화2.98±0.70차/분，교치료전위두수축폭도증대、수축빈솔가쾌。아립고서조치료전위배공시간위62.69±12.09min，치료후위64.81±12.16min，위두수축폭도、수축빈솔분별위2.68±0.83cm2화3±0.90차/분，치료후분별위2.62±0.73cm2화2.75±0.86차/분，아립고서조치료전후각항지표변화무명현차이。결론오담평조정신분렬증환자위배공가쾌，위두수축폭도증대、수축빈솔가쾌，위동력개변시환자체중증가적발병궤제지일，아립고서조환자위배공공능무명현변화。
Objective To explore the influence of ultrasonography patients with first-episode Schizophrenia on gastric emptying.Methods 40 patients with first-episode schizophrenia were randomly divided into olanzipine group(20 cases)and aripiprazole group(20 cases)for 4 weeks treatment.Gastric emptying time、antral contraction frequency and antral aera were measured using B-ultrasonography before treatment,Gastric emptying Function was reviewed 4 weeks after treatment.The efficacies of both drugs were assessed. Results In olanzipine group,Gastric emptying time Were 57.04 ± 9.86 min before treatment,after treatment were52.35 ± 9.86 min,the time were quicker than before treatment.antral contraction amplitude and contraction frequency were2.09 ± 0.59cm2 and 2.72 ± 0.35 times/min in olanzipine group,after treatment were 2.60 ± 0.73cm2 和 2.98 ± 0.70 times/min in olanzipine group,increased significantly after the treatment (P<0.05).In aripiprazole group,total emptying time were 62.69 ± 12.09 min before treatment,after treatment were 64.81 ± 12.16min,antral contraction amplitude and contraction frequency were 2.68± 0.83cm2和3± 0.90 times/min,after treatment were 2.62± 0.73cm2和2.75± 0.86 times/min,Each indexes of aripiprazole group were not changed after the teatment (P>0.05).Conclusion Gastric empyting rate is quiker than before treatment of olanzapine,the change of gastric emptying rate maybe is one of the fators of obesity in weight weight gain. Each indexes of aripiprazole group were not changed.