国际眼科杂志
國際眼科雜誌
국제안과잡지
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
2014年
9期
1717-1719
,共3页
寇列玲%杨立平%刘伟%张海波%李明
寇列玲%楊立平%劉偉%張海波%李明
구렬령%양립평%류위%장해파%리명
自体角膜缘干细胞%双层生物羊膜%翼状胬肉%复发率
自體角膜緣榦細胞%雙層生物羊膜%翼狀胬肉%複髮率
자체각막연간세포%쌍층생물양막%익상노육%복발솔
auto - corneallimbus stem cell%double biological amniotic membrane%pterygium%recurrence rate
目的：观察自体角膜缘干细胞移植联合双层生物羊膜移植治疗翼状胬肉的有效性和安全性。<br> 方法：2010-06/2013-12我院手术的翼状胬肉患者,根据翼状胬肉分型分级不同,采取不同的手术方法,A 组应用自体角膜缘干细胞移植术,B 组应用自体角膜缘干细胞移植联合双层生物羊膜移植术,术后随访6~36mo,观察术后复发率。<br> 结果：共有149例155眼纳入本研究。其中 A 组75眼应用自体角膜缘干细胞移植术：单薄型2级10眼中1眼复发,3级14眼中2眼复发；肥厚型17眼中2眼复发；复发型21眼中3眼复发。痊愈68眼,复发8眼,总复发率10.67%。 B 组80眼应用自体角膜缘干细胞移植联合双层生物羊膜移植,单薄型3级及4级以上无复发；肥厚型21眼中1眼复发；复发型37眼中2眼复发。痊愈77眼,复发3眼,总复发率3.75%。两组在肥厚型和复发型降低复发率方面有显著统计学意义(P<0.05)。<br> 结论：提示不同类型的胬肉采取不同的手术方式其手术复发率不同。自体角膜缘干细胞移植术适合于无根型、单薄型2级以下的翼状胬肉；自体角膜缘干细胞移植联合双层生物羊膜移植适合于单薄型2级以上、肥厚型、复发型的翼状胬肉手术治疗,复发率低,是一种理想的手术方法。
目的：觀察自體角膜緣榦細胞移植聯閤雙層生物羊膜移植治療翼狀胬肉的有效性和安全性。<br> 方法：2010-06/2013-12我院手術的翼狀胬肉患者,根據翼狀胬肉分型分級不同,採取不同的手術方法,A 組應用自體角膜緣榦細胞移植術,B 組應用自體角膜緣榦細胞移植聯閤雙層生物羊膜移植術,術後隨訪6~36mo,觀察術後複髮率。<br> 結果：共有149例155眼納入本研究。其中 A 組75眼應用自體角膜緣榦細胞移植術：單薄型2級10眼中1眼複髮,3級14眼中2眼複髮；肥厚型17眼中2眼複髮；複髮型21眼中3眼複髮。痊愈68眼,複髮8眼,總複髮率10.67%。 B 組80眼應用自體角膜緣榦細胞移植聯閤雙層生物羊膜移植,單薄型3級及4級以上無複髮；肥厚型21眼中1眼複髮；複髮型37眼中2眼複髮。痊愈77眼,複髮3眼,總複髮率3.75%。兩組在肥厚型和複髮型降低複髮率方麵有顯著統計學意義(P<0.05)。<br> 結論：提示不同類型的胬肉採取不同的手術方式其手術複髮率不同。自體角膜緣榦細胞移植術適閤于無根型、單薄型2級以下的翼狀胬肉；自體角膜緣榦細胞移植聯閤雙層生物羊膜移植適閤于單薄型2級以上、肥厚型、複髮型的翼狀胬肉手術治療,複髮率低,是一種理想的手術方法。
목적：관찰자체각막연간세포이식연합쌍층생물양막이식치료익상노육적유효성화안전성。<br> 방법：2010-06/2013-12아원수술적익상노육환자,근거익상노육분형분급불동,채취불동적수술방법,A 조응용자체각막연간세포이식술,B 조응용자체각막연간세포이식연합쌍층생물양막이식술,술후수방6~36mo,관찰술후복발솔。<br> 결과：공유149례155안납입본연구。기중 A 조75안응용자체각막연간세포이식술：단박형2급10안중1안복발,3급14안중2안복발；비후형17안중2안복발；복발형21안중3안복발。전유68안,복발8안,총복발솔10.67%。 B 조80안응용자체각막연간세포이식연합쌍층생물양막이식,단박형3급급4급이상무복발；비후형21안중1안복발；복발형37안중2안복발。전유77안,복발3안,총복발솔3.75%。량조재비후형화복발형강저복발솔방면유현저통계학의의(P<0.05)。<br> 결론：제시불동류형적노육채취불동적수술방식기수술복발솔불동。자체각막연간세포이식술괄합우무근형、단박형2급이하적익상노육；자체각막연간세포이식연합쌍층생물양막이식괄합우단박형2급이상、비후형、복발형적익상노육수술치료,복발솔저,시일충이상적수술방법。
To observe the effectiveness and safety of auto-corneallimbus stem cell transplantation combined double biological amniotic membrane transplantation in the treatment of pterygium <br> ●METHODS: The patients performed pterygium surgeries in our hospital between 2010 - 06 and 2013 - 12 were selected, according to different pterygium classification grading, different surgical methods were taken. Group A: autologous corneal limbus stem cell transplantation was conducted. Group B: autologous corneal limbus stem cell transplantation combined double biological amniotic membrane transplantation were conducted. The patients were followed up 6-36mo after operation, the postoperative recurrence rate was observed. <br> ●RESULTS: A total of 149 cases with 155 eyes included in this study, including 75 eyes in group A with the application of autologous limbal stem cell transplantation: thin type grade 2, 10 eyes ( 1 eye recurred ), grade 3, 14 eyes ( 2 eyes recurred );Hypertrophic 17 eyes (2 eyes recurred); Recurrence type 21 eyes (3 eyes recurred); Recovered 68 eyes (8 eyes recurred, the total recurrence rate was 10. 67%); Group B: 80 eyes treated with autologous limbal stem cell transplantation combined double biological amniotic membrane transplantation, thin type above grade 3 and grade 4 ( no recurrence); Hypertrophic 21 eyes (1 eye recurred); Recurrence type 37 eyes (2 eyes recurred);Recovered 77 eyes (3 eyes recurred, the recurrence rate was 3. 75%). Two groups of hypertrophic type, recurrence is significant in reducing the recurrence rate (P<0. 05). <br> ●CONCLUSlON: lt indicates that recurrence rates are different when adopting different ways of operations. Autologous corneal limbus stem cell transplantation is applicable for no root type, pterygium of thin type below grade 2; Autologous corneal limbus stem cell transplantation with double biological amniotic membrane transplantation is suitable for thin type above grade 2, hypertrophic type, recurrent type of pterygium, with low recurrence rate, so it is the ideal surgical method.
