国际眼科杂志
國際眼科雜誌
국제안과잡지
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
2014年
9期
1646-1648
,共3页
糖尿病视网膜病变%贝伐单抗%玻璃体切割
糖尿病視網膜病變%貝伐單抗%玻璃體切割
당뇨병시망막병변%패벌단항%파리체절할
diabetic retinopathy%Bevacizumab%vitrectomy
目的：探讨增殖性糖尿病视网膜病变(proliferative diabetic retinopathy,PDR)患者玻璃体切割(PPV)术前行玻璃体腔内注射贝伐单抗(Bevacizumab)对玻璃体手术的疗效及安全性的影响。
<br> 方法：对74例80眼 PDR 患者进行回顾性研究,74例80眼患者随机分为玻璃体切割术组(对照组)和玻璃体切割术联合贝伐单抗注射组(观察组),观察组行玻璃体切割术前10d 注射贝伐单抗。观察比较两组手术时间、术后视力、眼压、并发症及术中和术后出血情况。
<br> 结果：手术时间：观察组平均手术时间108±20.6min,对照组平均手术时间129±32.4min。术后视力：观察组术后平均视力0.32±0.20,对照组为0.21±0.16,两组相比存在显著性差异( P<0.05)。观察组术后3mo 眼压平均为21.3±7.2mmHg,对照组为20.6±6.7mmHg,两组相比,无显著性差异( P>0.05)。
<br> 结论：Bevacizumab 能使活跃的新生血管膜纤维化,剥膜过程中出血减少,手术视野清晰,手术时间缩短,术后获得更好的视力,未出现严重并发症。
目的：探討增殖性糖尿病視網膜病變(proliferative diabetic retinopathy,PDR)患者玻璃體切割(PPV)術前行玻璃體腔內註射貝伐單抗(Bevacizumab)對玻璃體手術的療效及安全性的影響。
<br> 方法：對74例80眼 PDR 患者進行迴顧性研究,74例80眼患者隨機分為玻璃體切割術組(對照組)和玻璃體切割術聯閤貝伐單抗註射組(觀察組),觀察組行玻璃體切割術前10d 註射貝伐單抗。觀察比較兩組手術時間、術後視力、眼壓、併髮癥及術中和術後齣血情況。
<br> 結果：手術時間：觀察組平均手術時間108±20.6min,對照組平均手術時間129±32.4min。術後視力：觀察組術後平均視力0.32±0.20,對照組為0.21±0.16,兩組相比存在顯著性差異( P<0.05)。觀察組術後3mo 眼壓平均為21.3±7.2mmHg,對照組為20.6±6.7mmHg,兩組相比,無顯著性差異( P>0.05)。
<br> 結論：Bevacizumab 能使活躍的新生血管膜纖維化,剝膜過程中齣血減少,手術視野清晰,手術時間縮短,術後穫得更好的視力,未齣現嚴重併髮癥。
목적：탐토증식성당뇨병시망막병변(proliferative diabetic retinopathy,PDR)환자파리체절할(PPV)술전행파리체강내주사패벌단항(Bevacizumab)대파리체수술적료효급안전성적영향。
<br> 방법：대74례80안 PDR 환자진행회고성연구,74례80안환자수궤분위파리체절할술조(대조조)화파리체절할술연합패벌단항주사조(관찰조),관찰조행파리체절할술전10d 주사패벌단항。관찰비교량조수술시간、술후시력、안압、병발증급술중화술후출혈정황。
<br> 결과：수술시간：관찰조평균수술시간108±20.6min,대조조평균수술시간129±32.4min。술후시력：관찰조술후평균시력0.32±0.20,대조조위0.21±0.16,량조상비존재현저성차이( P<0.05)。관찰조술후3mo 안압평균위21.3±7.2mmHg,대조조위20.6±6.7mmHg,량조상비,무현저성차이( P>0.05)。
<br> 결론：Bevacizumab 능사활약적신생혈관막섬유화,박막과정중출혈감소,수술시야청석,수술시간축단,술후획득경호적시력,미출현엄중병발증。
To discuss the effects and security of the application of intravitreous bevacizumab ( lVB ) before pars plana vitrectomy ( PPV ) in proliferative diabetic retinopathy (PDR).
<br> ●METHODS: Retrospective study of 74 patients (80 eyes) with PDR. These patients were randomly divided into two groups, some patients in PPV group and others patients in PPV+lVB group. The PPV+lVB group were treated with lVB 10d before operation. The operating time, postoperative eyesight, intraocular pressure ( lOP ), complications and bleeding during operation and postoperation between the two groups were observed and compared.
<br> ● RESULTS: Operating time and postoperative visual acuity were significantly different between the two groups. Operating time: with an average of 108±20. 6min of test group and 129 ± 32. 4min of comparison group. Postoperative visual acuity: with an average of 0. 32±0. 20 and 0. 21± 0. 16, there was significantly different between the two groups(P< 0. 05). Three months after operation, lOP was no significantly different between the two groups with an average of 21. 3±7. 2mmHg and 20. 6±6. 7mmHg(P>0. 05).
<br> ● CONCLUSlON: Bevacizumab can make active neovascular membranes fibrosis, reduce bleeding in the strip membranes process, so as to make the operation field clear, and can shorten the surgical time and get the better sight, no serious complications during postoperative period appeared.
