化工进展
化工進展
화공진전
CHEMICAL INDUSTRY AND ENGINEERING PROGRESS
2014年
9期
2403-2408
,共6页
赖氨酸接枝海藻酸盐%微胶珠%正交设计%优化
賴氨痠接枝海藻痠鹽%微膠珠%正交設計%優化
뢰안산접지해조산염%미효주%정교설계%우화
lysine grafted alginate%micro-bead%orthogonal design%optimization
为了提高海藻酸钙胶珠的稳定性，采用海藻酸盐的改性材料 ALG-g-Lys 制备微胶珠，通过单因素考察结合正交设计优化了 ALG-g-Lys微胶珠的制备工艺。优化后的制备工艺为：ALG-g-Lys 浓度为15g/L，电压为8.0kV，推进速度为30mm/h，针头型号为24G，CaCl2浓度为15g/L。优化后制得的微胶珠粒径均匀，球形度好，拖尾率、半球率和小球率小，平均粒径为253±40μm。该工作提供了一种新型的载体材料替代海藻酸盐作为凝胶材料，未来可适用于医药、食品行业等领域。
為瞭提高海藻痠鈣膠珠的穩定性，採用海藻痠鹽的改性材料 ALG-g-Lys 製備微膠珠，通過單因素攷察結閤正交設計優化瞭 ALG-g-Lys微膠珠的製備工藝。優化後的製備工藝為：ALG-g-Lys 濃度為15g/L，電壓為8.0kV，推進速度為30mm/h，針頭型號為24G，CaCl2濃度為15g/L。優化後製得的微膠珠粒徑均勻，毬形度好，拖尾率、半毬率和小毬率小，平均粒徑為253±40μm。該工作提供瞭一種新型的載體材料替代海藻痠鹽作為凝膠材料，未來可適用于醫藥、食品行業等領域。
위료제고해조산개효주적은정성，채용해조산염적개성재료 ALG-g-Lys 제비미효주，통과단인소고찰결합정교설계우화료 ALG-g-Lys미효주적제비공예。우화후적제비공예위：ALG-g-Lys 농도위15g/L，전압위8.0kV，추진속도위30mm/h，침두형호위24G，CaCl2농도위15g/L。우화후제득적미효주립경균균，구형도호，타미솔、반구솔화소구솔소，평균립경위253±40μm。해공작제공료일충신형적재체재료체대해조산염작위응효재료，미래가괄용우의약、식품행업등영역。
A new material,ALG-g-Lys,was used to prepare micro-beads instead of alginate to improve the stability of alginate micro-beads. The preparation process was optimized using the single factor method combined with orthogonal design. The optimized parameters were:ALG-g-Lys concentration 1.5g/L,voltage 8.0kV,advance speed 30mm/h,needle 24G,and CaCl2 concentration 15g/L. The prepared micro-beads showed even distribution and good sphericity with low trailing ratio,half sphere ratio and globule ratio. The mean particle size was 253±40μm. This work supplies a novel carrier material instead of alginate to prepare gel, showing bright future in medicine and food industries.
