海南医学
海南醫學
해남의학
HAINAN MEDICAL JOURNAL
2014年
13期
1953-1955
,共3页
肺癌%Th17细胞%Tc17细胞
肺癌%Th17細胞%Tc17細胞
폐암%Th17세포%Tc17세포
Lung cancer%Thl7 cells%Tcl7 Cell
目的：对比白细胞介素(IL)-17+CD4+T (Th17)细胞和IL-17+CD8+T (Tc17)细胞在肺癌患者外周血中的表达水平。方法选择2010年3月至2013年3月我院接诊的70例肺癌患者进行研究(肺癌组)，同时选择40例健康体检者作为对照组。采用流式细胞术对两组的Th17细胞和Tcl7细胞表达情况进行检测并分析。结果检测发现，腺癌、鳞癌、小细胞癌三种病理类型患者的Th17细胞和Tcl7细胞表达水平差异无统计学意义(F=1.7621， P=0.1798；F=0.1613，P=0.8530)。表明Th17细胞和Tc17细胞表达水平与肺癌患者的病理类型无关。不同TNM分期的肺癌患者的Th17细胞和Tc17细胞表达水平差异有统计学意义(F=5.7831，P=0.0048；F=3.7514， P=0.0287)，且随着患者TNM分期的升高，Th17细胞和Tc17细胞表达水平也逐渐增高(P<0.05)。结论 Th17细胞和Tc17细胞在不同TNM分期肺癌患者的外周血中的表达水平不同，Th17细胞和Tc17细胞在肺癌患者中表达水平明显升高。
目的：對比白細胞介素(IL)-17+CD4+T (Th17)細胞和IL-17+CD8+T (Tc17)細胞在肺癌患者外週血中的錶達水平。方法選擇2010年3月至2013年3月我院接診的70例肺癌患者進行研究(肺癌組)，同時選擇40例健康體檢者作為對照組。採用流式細胞術對兩組的Th17細胞和Tcl7細胞錶達情況進行檢測併分析。結果檢測髮現，腺癌、鱗癌、小細胞癌三種病理類型患者的Th17細胞和Tcl7細胞錶達水平差異無統計學意義(F=1.7621， P=0.1798；F=0.1613，P=0.8530)。錶明Th17細胞和Tc17細胞錶達水平與肺癌患者的病理類型無關。不同TNM分期的肺癌患者的Th17細胞和Tc17細胞錶達水平差異有統計學意義(F=5.7831，P=0.0048；F=3.7514， P=0.0287)，且隨著患者TNM分期的升高，Th17細胞和Tc17細胞錶達水平也逐漸增高(P<0.05)。結論 Th17細胞和Tc17細胞在不同TNM分期肺癌患者的外週血中的錶達水平不同，Th17細胞和Tc17細胞在肺癌患者中錶達水平明顯升高。
목적：대비백세포개소(IL)-17+CD4+T (Th17)세포화IL-17+CD8+T (Tc17)세포재폐암환자외주혈중적표체수평。방법선택2010년3월지2013년3월아원접진적70례폐암환자진행연구(폐암조)，동시선택40례건강체검자작위대조조。채용류식세포술대량조적Th17세포화Tcl7세포표체정황진행검측병분석。결과검측발현，선암、린암、소세포암삼충병리류형환자적Th17세포화Tcl7세포표체수평차이무통계학의의(F=1.7621， P=0.1798；F=0.1613，P=0.8530)。표명Th17세포화Tc17세포표체수평여폐암환자적병리류형무관。불동TNM분기적폐암환자적Th17세포화Tc17세포표체수평차이유통계학의의(F=5.7831，P=0.0048；F=3.7514， P=0.0287)，차수착환자TNM분기적승고，Th17세포화Tc17세포표체수평야축점증고(P<0.05)。결론 Th17세포화Tc17세포재불동TNM분기폐암환자적외주혈중적표체수평불동，Th17세포화Tc17세포재폐암환자중표체수평명현승고。
Objective To study the expression levels of Interleukin IL-17+CD4+T (Th17) cells and IL-17+CD8+T (Tc17) cells in the peripheral blood of patients with lung cancer. Methods Seventy cases of lung cancer from March 2010 to March 2013 in our hospital were studied. And 40 healthy volunteers were selected as the con-trol group. Flow cytometry was used in both groups Th17 cells and Tc17 cell expression were detected and ana-lyzed. Results The difference of expression levels of Th17 and Tc17 cells were not found between adenocarcino-ma, squamous cell carcinoma and small cell carcinoma (F=1.762 1, P=0.179 8;F=0.161 3, P=0.853 0). This indi-cates that the expression levels of Th17 and Tc17 cells is independent of pathological types of lung cancer pa-tients. Statistical significance was found between the expression levels of Th17 and Tc17 cells in different TNM stages of lung cancer (F=5.783 1, P=0.004 8;F=3.751 4, P=0.028 7), and the expression of Th17 and Tc17 cells in patients with advanced disease (stageⅢ and Ⅳ) were significantly higher than in those with stage Ⅰ and Ⅱ (P<0.05). Conclusion We found that the expression levels of Th17 and Tc17 cells in the peripheral blood were differ-ent in different TNM stages of lung cancer, and Th17 cells and Tc17 cells in patients with lung cancer were in-crease significantly.
