CAJ | 학술논문

目的：研究葡萄糖6磷酸脱氢酶(G6PD)缺乏是否会加重新生儿高胆红素血症患儿的心肌损伤从而影响患儿血液中心肌酶的水平。方法选取2012年10月至2013年11月在我院出生的新生儿黄疸患儿190例，经检查后分组，将其中139例高胆红素血症患儿分为观察组，余51例生理性黄疸患儿分为对照组；观察组患儿根据G6PD是否正常再分为观察Ⅰ组79例(G6PD正常)和观察Ⅱ组60例（G6PD缺乏)，抽血检测所有患儿总胆红素(TBIL)、葡萄糖6磷酸脱氢酶(G6PD)、谷草转氨酶(AST)、乳酸脱氢酶(LDH)、肌酸激酶(CK)以及肌酸激酶同工酶(CK-MB)，并对检测结果进行比较分析。结果观察组中139例患儿的平均血清TBIL含量[(269.7±31.3)μmol/L]明显高于对照组[(186.5±19.8)μmol/L]，两者比较差异具有统计学意义(P<0.05)；观察组患儿血清中AST、LDH、CK、CK-MB等心肌酶的平均含量均明显高于对照组，差异均具有统计学意义(P<0.05)；观察Ⅱ组患儿与观察Ⅰ组患儿胆红素水平含量比较差异无统计学意义(P>0.05)，但观察Ⅱ组患儿AST、CK、CK-MB、LDH等心肌酶的平均含量均明显高于观察Ⅰ组，差异均具有统计学意义(P<0.05)。结论高胆红素血症可以对心肌细胞造成损伤从而引起心肌酶水平的变化，新生儿高胆红素血症患儿的心肌酶升高程度与其黄疸水平呈正相关；G6PD缺乏可增强高胆红素血症对心肌细胞造成的损伤。
목적：연구포도당6린산탈경매(G6PD)결핍시부회가중신생인고담홍소혈증환인적심기손상종이영향환인혈액중심기매적수평。방법선취2012년10월지2013년11월재아원출생적신생인황달환인190례，경검사후분조，장기중139례고담홍소혈증환인분위관찰조，여51례생이성황달환인분위대조조；관찰조환인근거G6PD시부정상재분위관찰Ⅰ조79례(G6PD정상)화관찰Ⅱ조60례（G6PD결핍)，추혈검측소유환인총담홍소(TBIL)、포도당6린산탈경매(G6PD)、곡초전안매(AST)、유산탈경매(LDH)、기산격매(CK)이급기산격매동공매(CK-MB)，병대검측결과진행비교분석。결과관찰조중139례환인적평균혈청TBIL함량[(269.7±31.3)μmol/L]명현고우대조조[(186.5±19.8)μmol/L]，량자비교차이구유통계학의의(P<0.05)；관찰조환인혈청중AST、LDH、CK、CK-MB등심기매적평균함량균명현고우대조조，차이균구유통계학의의(P<0.05)；관찰Ⅱ조환인여관찰Ⅰ조환인담홍소수평함량비교차이무통계학의의(P>0.05)，단관찰Ⅱ조환인AST、CK、CK-MB、LDH등심기매적평균함량균명현고우관찰Ⅰ조，차이균구유통계학의의(P<0.05)。결론고담홍소혈증가이대심기세포조성손상종이인기심기매수평적변화，신생인고담홍소혈증환인적심기매승고정도여기황달수평정정상관；G6PD결핍가증강고담홍소혈증대심기세포조성적손상。
Objective To explore whether the glucose-6-phosphate dehydrogenase (G6PD) deficiency will aggravate the myocardial injury in patients with neonatal hyperbilirubinaemia and influence the levels of neonate myo-cardial enzymes. Methods A total of190 children with hyperbilirubinemia who were born in our hospital from 2012 October to 2013 November were involved in this study. After examination, they were divided into observation group (139 children) and control group (51 children). According to the G6PD level, the observation group was divided into observation groupⅠ(79 cases with normal G6PD) and observation groupⅡ(60 cases with G6PD deficiency). TBIL, G6PD, AST, LDH, CK and CK-MB in the 190 children were detected and analyzed. Results The average content of TBIL in the observation group was significantly higher than that in the control group [(269.7 ± 31.3)μmol/L vs (186.5±19.8)μmol/L, P<0.05]. The average contents of AST, LDH, CK and CK-MB in the observation group was sig-nificantly higher than those in the control group (P<0.05);There was no significant difference in the average content of TBIL between the observation groupⅠand the observation groupⅡ(P>0.05), but the average contents of AST, LDH, CK and CK-MB in the observation group Ⅱ was significantly higher than that in the observation group Ⅰ(P<0.05). Conclusion Hyperbilirubinemia damaged myocardial cells and changed the myocardial enzyme content in serum. The myocardial enzyme level in patient with neonatal hyperbilirubinemia was positively correlated with jaundice. G6PD defi-ciency increased the damage on myocardial cells.