CAJ | 학술논문

目的：观察采用经鼓室内注入含庆大霉素明胶海绵泥浆进行化学性迷路切除治疗单侧顽固性梅尼埃病的临床疗效。方法对20例诊断为单侧顽固性梅尼埃病的患者通过鼓室内注入含庆大霉素明胶海绵泥浆进行化学性迷路切除（观察组），同时选取20例单侧顽固性梅尼埃病药物保守治疗患者作为临床对照（对照组）。观察两组患者治疗后眩晕发作、耳鸣情况、听力变化、生活工作能力恢复情况及并发症。结果观察组经过化学性迷路切除后，20例中有14例眩晕情况得到完全控制，控制率为75.0%。对照组中仅有3例眩晕情况得到完全控制，控制率为15.0%，两组比较差异有统计学意义(P<0.01)。此外，观察组患者耳鸣情况、听力变化、生活工作能力恢复情况等均优于对照组(P<0.01)。结论化学性迷路切除治疗单侧顽固性梅尼埃病疗效稳定确切，安全可靠。
목적：관찰채용경고실내주입함경대매소명효해면니장진행화학성미로절제치료단측완고성매니애병적림상료효。방법대20례진단위단측완고성매니애병적환자통과고실내주입함경대매소명효해면니장진행화학성미로절제（관찰조），동시선취20례단측완고성매니애병약물보수치료환자작위림상대조（대조조）。관찰량조환자치료후현훈발작、이명정황、은력변화、생활공작능력회복정황급병발증。결과관찰조경과화학성미로절제후，20례중유14례현훈정황득도완전공제，공제솔위75.0%。대조조중부유3례현훈정황득도완전공제，공제솔위15.0%，량조비교차이유통계학의의(P<0.01)。차외，관찰조환자이명정황、은력변화、생활공작능력회복정황등균우우대조조(P<0.01)。결론화학성미로절제치료단측완고성매니애병료효은정학절，안전가고。
Objective To observe the clinical curative effect of chemical labyrinthectomy in the treatment of intractable Meniere's disease by injecting gentamicin gelatin sponge mud into intratympanic. Methods Twenty patients with unilateral intractable Meniere's disease were treated with intratympanic injection of gelatin sponge mud soaked in gentamicin (observation group), and the other 20 with unilateral intractable Meniere's disease were given conservative treatment for (control group). The onset of vertigo, tinnitus, hearing change, life and work ability recovery and complica-tions were observed in two groups after treatment. Results In the observation group, 14 patients with vertigo was com-pletely controlled after chemical labyrinthectomy and the control rate was 75%. In the control group, only 3 patients with vertigo was completely controlled, and the control rate was 15%. There was a significant difference between the two groups (P<0.01). In addition, the improvement of tinnitus, hearing change, life and work ability recovery and complica-tions in the observation group were significantly bigger than those in the control group (P<0.01). Conclusion Chemi-cal treatment in unilateral labyrinthectomy intractable Meniere's disease is effective, stable, safe and reliable.