CAJ | 학술논문

目的：探索帕金森病(PD)患者多巴胺能药物与夜间主观和客观睡眠之间的关系。方法收集本院2010年10月至2013年6月门诊诊疗的帕金森病患者的人口学特征和疾病信息，所有患者行整夜视频多导睡眠图、完成PD睡眠量表(SCOPA-SLEEP)，采集用药信息，包括服药与就寝时间，转化为左旋多巴当量。结果共有41例男性、20例女性患者纳入研究，中位年龄63.6岁，中位病程5年。经过年龄、性别、疾病严重程度和病程校正，更高的左旋多巴等效剂量(LED4H)与更高的SCOPA-NS (P<0.05)及入睡后觉醒时间(P<0.05)相关。更高剂量就寝前多巴胺能药物摄入与快速动眼（REM）睡眠时间百分比减少相关(P<0.05)。结论就寝前服用更高剂量多巴胺能药物与更少的REM睡眠及更差的睡眠质量相关。尽管PD患者睡眠质量不佳由多种因素引起，但仍建议将睡前服药剂量和时间纳入帕金森病患者管理当中。
목적：탐색파금삼병(PD)환자다파알능약물여야간주관화객관수면지간적관계。방법수집본원2010년10월지2013년6월문진진료적파금삼병환자적인구학특정화질병신식，소유환자행정야시빈다도수면도、완성PD수면량표(SCOPA-SLEEP)，채집용약신식，포괄복약여취침시간，전화위좌선다파당량。결과공유41례남성、20례녀성환자납입연구，중위년령63.6세，중위병정5년。경과년령、성별、질병엄중정도화병정교정，경고적좌선다파등효제량(LED4H)여경고적SCOPA-NS (P<0.05)급입수후각성시간(P<0.05)상관。경고제량취침전다파알능약물섭입여쾌속동안（REM）수면시간백분비감소상관(P<0.05)。결론취침전복용경고제량다파알능약물여경소적REM수면급경차적수면질량상관。진관PD환자수면질량불가유다충인소인기，단잉건의장수전복약제량화시간납입파금삼병환자관리당중。
Objective To explore the correlation between dopaminergic medications and subjective and ob-jective nocturnal sleep in patients with Parkinson's disease (PD). Methods Patients with PD were recruited from the outpatient clinic in our hospital from September 2010 to June 2013, whose demographic characteristics and disease in-formation were collected. All patients underwent one-night polysomnography and responded to SCOPA-SLEEP. Medi-cation intake information including medication time and bedtime were obtained and converted to levodopa equiva-lents. Results 41 males patients and 20 females patients were enrolled in this study, whose median age was 63.6 years and the median duration of disease was 5 years. After the adjusting for age, sex, disease severity and disease du-ration, greater total levodopa equivalent intake within 4h was correlated to higher total SCOPA-nighttime score (P<0.05) and greater wake time after sleep onset (P<0.05). Greater dopaminergic medication intake prior to sleep was also correlated to less percentage of rapid eye movement (REM) sleep in total sleep time (P<0.05). Conclusion Higher doses of dopaminergic medications intake prior to sleep were correlated to worse sleep quality and less REM sleep. Al-though poor nocturnal sleep in patients with PD is multi-factorial in etiology, our findings suggest that timing and dos-es of medications prior to sleep need to be considered in the management of patients with PD.