CAJ | 학술논문

目的：探讨乳腺癌组织中PTEN蛋白表达与血清多效生长因子(Pleiotrophin, PTN)水平的关系。方法采用免疫组化检测52例乳腺癌组织中PTEN蛋白表达，采用特异性酶联免疫吸附实验检测该组患者术前血清PTN水平。结果 PTEN阴性组36例，血清PTN平均值(566.34+464.51) pg/ml；PTEN阳性组16例，血清PTN平均值(408.68+170.77) pg/ml。两组比较血清PTN平均水平差异无统计学意义。结论乳腺癌的发生发展是一个复杂的过程，在乳腺癌的发生发展中PTEN和PTN或许是相互独立的因素，它们之间的关系还需要更多的证据来证明。
목적：탐토유선암조직중PTEN단백표체여혈청다효생장인자(Pleiotrophin, PTN)수평적관계。방법채용면역조화검측52례유선암조직중PTEN단백표체，채용특이성매련면역흡부실험검측해조환자술전혈청PTN수평。결과 PTEN음성조36례，혈청PTN평균치(566.34+464.51) pg/ml；PTEN양성조16례，혈청PTN평균치(408.68+170.77) pg/ml。량조비교혈청PTN평균수평차이무통계학의의。결론유선암적발생발전시일개복잡적과정，재유선암적발생발전중PTEN화PTN혹허시상호독립적인소，타문지간적관계환수요경다적증거래증명。
Objective To investigate the expression of PTEN in breast cancer tissues and the level of pleiotrophin in breast cancer serums and study its relationship. Methods Using immunohistochemical to detect the expression of PTEN protein in breast cancer tissues of 52 cases, and using specific enzyme-linked immunosorbent experiment to test the level of PTN in preoperative serum of patients in this group. Results There were 36 patients in PTEN negative group with an average serum PTN value as (566.34+464.51) pg/ml, while there were 16 cases in PTEN positive group with an average serum PTN value as (408.68+170.77) pg/ml. There was no statistically significant difference in the average serum PTN values between the two groups. Conclusion The development of breast cancer is a complicated process. In the development of breast cancer, PTN and PTEN may be independent of each other, and the relationship between them still needs more evidence to prove.