CAJ | 학술논문

目的：采用中草药制剂神农百解方干预鼻咽癌放疗全过程，客观评价其对放射性口干的疗效，以期为临床防治放射性口干提供新的干预手段。方法80例鼻咽癌初治患者随机分成观察组(中草药+放化疗)和对照组(单纯放化疗)，各40例。于放疗前、DT 36 Gy、DT 60 Gy、全程放疗结束及结束后4周行口干程度评价和唾液流率测定。结果放疗过程中所有病例均出现口干反应：在DT 36 Gy时，观察组以轻度口干(G2)为多，占20例(50.0%)，而对照组以中度口干(G2)为多，占19例(47.5%)；随着照射剂量的增加，口干程度呈加重趋势，但观察组中、重度口干的发生率明显低于对照组。其中在DT 60 Gy时，对照组G320例(50.0%)明显高于观察组G310例(25.0%)，差异有统计学意义(P<0.01)。在唾液流率监测方面，随着放疗剂量的增加，两组患者放疗后各时段的唾液流率均有下降，与对照组相同时段比较，观察组的唾液流率较对照组高，差异有统计学意义(P<0.01)。结论中草药制剂神农百解方安全有效、价格低廉、服用方便，能有效减轻患者口干症状，可以作为临床防治放射性口干燥症的一种新的治疗手段。
목적：채용중초약제제신농백해방간예비인암방료전과정，객관평개기대방사성구간적료효，이기위림상방치방사성구간제공신적간예수단。방법80례비인암초치환자수궤분성관찰조(중초약+방화료)화대조조(단순방화료)，각40례。우방료전、DT 36 Gy、DT 60 Gy、전정방료결속급결속후4주행구간정도평개화타액류솔측정。결과방료과정중소유병례균출현구간반응：재DT 36 Gy시，관찰조이경도구간(G2)위다，점20례(50.0%)，이대조조이중도구간(G2)위다，점19례(47.5%)；수착조사제량적증가，구간정도정가중추세，단관찰조중、중도구간적발생솔명현저우대조조。기중재DT 60 Gy시，대조조G320례(50.0%)명현고우관찰조G310례(25.0%)，차이유통계학의의(P<0.01)。재타액류솔감측방면，수착방료제량적증가，량조환자방료후각시단적타액류솔균유하강，여대조조상동시단비교，관찰조적타액류솔교대조조고，차이유통계학의의(P<0.01)。결론중초약제제신농백해방안전유효、개격저렴、복용방편，능유효감경환자구간증상，가이작위림상방치방사성구간조증적일충신적치료수단。
Objective To observe the curative effect of Shennong baijie decoction in the intervention of ra-dioactive dry mouth disease in the whole process of nasopharyngeal carcinoma radiotherapy, so as to provide a new in-tervention for clinical prevention and treatment of radioactive dry mouth. Methods Eighty patients with nasopharyn-geal carcinoma were randomly divided into observation group (Chinese herbal medicine+radiation and chemotherapy) and control group (simple radiation and chemotherapy), with 40 cases in each. Line dry mouth degree evaluation and saliva flow rate measurement were performed at different time points, such as before radiotherapy, DT 36 Gy, DT 60 Gy, the end of radiotherapy, and 4 weeks after the end of radiotherapy. Results Dry mouth radiation reaction oc-curred in all cases. When treated with DT 36 Gy, in the observation group, the mild dry mouth (G1) was the most, which accounted for 50.0%(20 cases), while in the control group, the moderate dry mouth (G3) was the most, which accounted for 47.5%(19 cases). With the increase of irradiation dose, mouth dry degree showed a trend of increase. The incidence of severe dry mouth in the observation group was significantly lower than that in the control group. When treated with DT 60 Gy, G3 in the control group was statistically significantly higher than that in the observation group [20 cases (50.0%) vs 10 cases (25.0%), P<0.01]. In terms of saliva flow rate monitoring, with the increase of ra-diation dose, the saliva flow rates declined in the two groups at each radiotherapy period. Meanwhile, compared with the control group in the same time, saliva flow rate was statistically significantly higher in the observation group (P<0.05). Conclusion Shennong baijie decoction is safe, effective, low cost and convenient taking, which could effec-tively relieve dry mouth in patients with symptoms, and could be used as a new therapy in clinical prevention and treat-ment of radioactive dry mouth disease.