CAJ | 학술논문

雄激素受体（androgen receptor，AR）作为核内转录因子是前列腺癌中最常见的治疗靶标，在去势抵抗性前列腺癌（castration resistant prostate cancer，CRPC）中雄激素受体也起到了非常重要的作用。去势抵抗性前列腺癌的发生发展机制是当前的研究热点。表观遗传学的改变在前列腺癌的发展中具有重要作用。甲基化、乙酰化及非编码RNA可以通过对雄激素受体信号通路的调控促进或者抑制前列腺癌的发生发展。本文将近期关于前列腺癌雄激素受体信号通路表观遗传学的调节机制进行综述。
웅격소수체（androgen receptor，AR）작위핵내전록인자시전렬선암중최상견적치료파표，재거세저항성전렬선암（castration resistant prostate cancer，CRPC）중웅격소수체야기도료비상중요적작용。거세저항성전렬선암적발생발전궤제시당전적연구열점。표관유전학적개변재전렬선암적발전중구유중요작용。갑기화、을선화급비편마RNA가이통과대웅격소수체신호통로적조공촉진혹자억제전렬선암적발생발전。본문장근기관우전렬선암웅격소수체신호통로표관유전학적조절궤제진행종술。
The androgen receptor (AR), a nuclear hormone and transcription factor, is the most therapeutic relevant target in pros-tate cancer (PCa) and in the castration-resistant prostate cancer (CRPC). Significant efforts have been focused on understanding the mechanisms involved in the development and progression of CRPC. Recent work has revealed the importance of epigenetic events in-cluding the regulation of AR signaling by methylation, acetylation, and non-coding RNA in the tumorigenesis and development of PCa. We summarize recent findings on the mechanisms of epigenetic regulation of AR signaling in PCa.