CAJ | 학술논문

目的：探讨人乳头瘤病毒（HPV）分型检测在维吾尔族和汉族宫颈癌机会性筛查中的意义。方法：采用宫颈细胞学检查和HPV分型检测对1140例患者行宫颈癌机会性筛查，共438例患者在阴道镜下行宫颈活检，评价HPV分型检测的诊断价值。结果：1140例HPV总感染率为30.3%（345/1140），检出的高危型HPV主要型别依次为HPV16、58、52、18、45型。汉族HPV52型感染率高于维吾尔族，差异具有统计学意义（χ2=8.737，P=0.003）。1140例患者中单一感染率为22.4%（255/1140），多重感染率为6.1%（69/1140），HPV分型检测诊断宫颈病变的灵敏度为86.4%（209/242）、特异度为24.5%（48/196）、阳性预测值为58.5%（209/357）、阴性预测值为59.3%（48/81）。结论：维吾尔族和汉族HPV感染型别各有其自身特点，HPV分型检测对宫颈病变的诊断有重要价值。
목적：탐토인유두류병독（HPV）분형검측재유오이족화한족궁경암궤회성사사중적의의。방법：채용궁경세포학검사화HPV분형검측대1140례환자행궁경암궤회성사사，공438례환자재음도경하행궁경활검，평개HPV분형검측적진단개치。결과：1140례HPV총감염솔위30.3%（345/1140），검출적고위형HPV주요형별의차위HPV16、58、52、18、45형。한족HPV52형감염솔고우유오이족，차이구유통계학의의（χ2=8.737，P=0.003）。1140례환자중단일감염솔위22.4%（255/1140），다중감염솔위6.1%（69/1140），HPV분형검측진단궁경병변적령민도위86.4%（209/242）、특이도위24.5%（48/196）、양성예측치위58.5%（209/357）、음성예측치위59.3%（48/81）。결론：유오이족화한족HPV감염형별각유기자신특점，HPV분형검측대궁경병변적진단유중요개치。
Objective:This study investigates the significance of human papilloma virus (HPV) subtype detection in opportunis-tic screening for cervical cancer in Uygur and Han women. Methods:Flow-through hybridization gene chip and thin-prep cytology test were used to detect HPV in cervical cell samples from 1140 females. A total of 428 patients had undergone cervical biopsies through colposcopy. The diagnostic results of the HPV subtype test for cervical lesions were evaluated on the basis of histology. Results:Total HPV infection rate for the 1140 cervical samples was 30.3%. The most common HPV subtypes were HPV16, HPV58, HPV52, HPV18, and HPV45. HPV52 infection rate was higher in Han women than in Uygur women, with statistically significant differences between the two (χ2=8.737, P=0.003). Among these cervical samples, the single HPV infection rate was 22.4%(255/1140), whereas the multiple HPV infection rate was 6.1% (69/1140). The sensitivity and specificity of the HPV subtype test for cervical lesions were 86.4% and 24.5%, respectively. The positive and negative predictive values were 58.5%and 59.3%. Conclusion:HPV infection subtypes in Ugyur and Han women have unique characteristics. Subtype detection is important in opportunistic screening for cervical cancer.