CAJ | 학술논문

目的：探讨胰岛素低血糖合并药物治疗抑郁症的临床疗效及安全性。方法：选择108例符合 CCMD-3关于抑郁症的诊断标准的患者，按入院时间随机将患者分为研究组及对照组各54例，疗程为1个月。对照组患者使用常规药物治疗，研究组患者联用胰岛素低血糖治疗。于患者治疗前，治疗后1、2、4周末采用汉密尔顿抑郁量表，不良反应量表评定疗效及不良反应。结果：两组患者的治疗均有效，但研究组患者起效时间明显优于对照组，研究组患者的有效率70.37%，明显高于对照组的51.85%，差异有统计学意义(P<0.05)。两组患者治疗过程中出现的不良反应无明显差异。结论：胰岛素低血糖辅助治疗抑郁症，起效快，疗效更为显著，不增加不良反应。
목적：탐토이도소저혈당합병약물치료억욱증적림상료효급안전성。방법：선택108례부합 CCMD-3관우억욱증적진단표준적환자，안입원시간수궤장환자분위연구조급대조조각54례，료정위1개월。대조조환자사용상규약물치료，연구조환자련용이도소저혈당치료。우환자치료전，치료후1、2、4주말채용한밀이돈억욱량표，불량반응량표평정료효급불량반응。결과：량조환자적치료균유효，단연구조환자기효시간명현우우대조조，연구조환자적유효솔70.37%，명현고우대조조적51.85%，차이유통계학의의(P<0.05)。량조환자치료과정중출현적불량반응무명현차이。결론：이도소저혈당보조치료억욱증，기효쾌，료효경위현저，불증가불량반응。
Objective:To investigate safety and clinical efficacy of insulin hypoglycemia combined with drug treatment for de-pression. Methods:A total of 108 cases meeting CCMD-3 criteria for depression were selected. According to the admission time, they were randomly divided into study group and control group, each with 54 cases, and accepted a 1 month's treatment. The cases in con-trol group received the routine medicine, while those in study group received insulin hypoglycemia combined with drug treatment. Ham-ilton depression scale (HAMD) and treatment emergent symptom scale (TESS) were used before and 1, 2, 4 weeks after the treatment to assess the efficacy and adverse reactions. Results: The treatments of the two groups were effective, but the onset time of study group was superior than that of control group. The effective rate of study group (70. 37% ) was significantly higher than that of control group (51. 85% ), and the difference was statistically significant (P<0. 05). There were no significant differences in the adverse reactions during the treatment between the two groups. Conclusions: Insulin hypoglycemia in the adjuvant treatment of depression has a rapid on-set, more significant effect, and no increase in the adverse reactions.