CAJ | 학술논문

经皮冠状动脉内支架植入术已经成为冠心病的主要有效治疗方法之一，然而再狭窄的发生仍然是术后的主要隐患，支架异物及其对血管壁的机械损伤不可避免地成为了再狭窄的始动因素，随后激活血小板及一系列炎症细胞，炎症细胞及内皮细胞释放多种炎症介质，从而激活过度的炎症反应，最终导致血管平滑肌细胞的迁移和增殖、细胞外基质的堆积、新生内膜形成、血管重构，引起再狭窄。炎症反应作为再狭窄的中心环节一直是我们破解再狭窄的切入点，而含铜不锈钢材料在多种试验中证实具有抗菌、促进内皮细胞增殖及早期凋亡的特性。本研究就再狭窄与中心环节的炎症反应和铜材料的抑制过度炎症反应作用做一探讨。
경피관상동맥내지가식입술이경성위관심병적주요유효치료방법지일，연이재협착적발생잉연시술후적주요은환，지가이물급기대혈관벽적궤계손상불가피면지성위료재협착적시동인소，수후격활혈소판급일계렬염증세포，염증세포급내피세포석방다충염증개질，종이격활과도적염증반응，최종도치혈관평활기세포적천이화증식、세포외기질적퇴적、신생내막형성、혈관중구，인기재협착。염증반응작위재협착적중심배절일직시아문파해재협착적절입점，이함동불수강재료재다충시험중증실구유항균、촉진내피세포증식급조기조망적특성。본연구취재협착여중심배절적염증반응화동재료적억제과도염증반응작용주일탐토。
Percutaneous coronary stent implantation has become one of the main effective methods of coronary heart disease , however ,restenosis remains a major risk of postoperative stent foreign objects and mechanical damage to the vessel wall inevitably become a restenosis initiating factor , platelet activation and subsequent series of inflammatory cells , inflammatory cells and endothelial cells release a variety of inflammatory mediators , thereby activating the excessive inflammatory response , resulting in the accumulation of vascular smooth muscle cell migration and proliferation , extracellular matrix ,neointimal formation ,vascular remodeling ,causing restenosis .Inflammation as a central part of restenosis has been our starting point to crack restenosis ,while copper has antibacterial stainless steel confirmed in a variety of tests ,to promote appreciation and early apoptotic endothelial cells .The study on restenosis and inflammation and suppress the central link of the copper material over the role of inflammation does a discussion .