中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2013年
8期
728-730
,共3页
脑卒中后抑郁%脑卒中后认知功能障碍%氢质子磁共振波谱%额叶%丘脑%海马
腦卒中後抑鬱%腦卒中後認知功能障礙%氫質子磁共振波譜%額葉%丘腦%海馬
뇌졸중후억욱%뇌졸중후인지공능장애%경질자자공진파보%액협%구뇌%해마
Post stroke depression%Post stroke cognitive impairment%Proton magnetic resonance spectroscopy%Frontal lobe%Hippocampus japonicas%Thalamus
目的 研究脑卒中后抑郁(PSD)患者和脑卒中后认知功能损害(PSCI)患者的氢质子磁共振波谱(1H-MRS)表现,探讨脑卒中后抑郁和认知功能损害之间的关系.方法 连续选取武汉大学中南医院2012年1月至2012年12月急性脑卒中患者82名,根据根据中国精神疾病分类方案与诊断标准第3版和血管性认知功能损害的专家共识将患者分为合并有认知功能损害的PSD组(A组)19例,PSD组(B组)21例,PSCI组(C组)22例,和没有抑郁和认知功能损害的对照组(D组)20例,分别在卒中发病一月以内给予1 H-MRS检查,对各组结果进行统计分析.结果 没有发现PSD和PSCI之间有明显的相互关系.同时患有PSD和PSCI的患者海马Cho/Cr比值[左侧(1.05±0.10),右侧(1.18±0.15)],高于其它各组[B组左侧(0.84±0.10),右侧(0.88±0.08)；C组左侧(0.88±0.08)右侧(0.87±0.07)；D组左侧(0.87±0.06),右侧(0.89±0.06)],差异有统计学意义(P＜0.05).PSD和PSCI都可使海马Cho/Cr比值升高,且有交互促进作用.结论 未发现PSD和PSCI在疾病发生层面存在明显相关关系,两者并发时会对海马胆碱代谢异常产生交互促进作用.
目的 研究腦卒中後抑鬱(PSD)患者和腦卒中後認知功能損害(PSCI)患者的氫質子磁共振波譜(1H-MRS)錶現,探討腦卒中後抑鬱和認知功能損害之間的關繫.方法 連續選取武漢大學中南醫院2012年1月至2012年12月急性腦卒中患者82名,根據根據中國精神疾病分類方案與診斷標準第3版和血管性認知功能損害的專傢共識將患者分為閤併有認知功能損害的PSD組(A組)19例,PSD組(B組)21例,PSCI組(C組)22例,和沒有抑鬱和認知功能損害的對照組(D組)20例,分彆在卒中髮病一月以內給予1 H-MRS檢查,對各組結果進行統計分析.結果 沒有髮現PSD和PSCI之間有明顯的相互關繫.同時患有PSD和PSCI的患者海馬Cho/Cr比值[左側(1.05±0.10),右側(1.18±0.15)],高于其它各組[B組左側(0.84±0.10),右側(0.88±0.08)；C組左側(0.88±0.08)右側(0.87±0.07)；D組左側(0.87±0.06),右側(0.89±0.06)],差異有統計學意義(P＜0.05).PSD和PSCI都可使海馬Cho/Cr比值升高,且有交互促進作用.結論 未髮現PSD和PSCI在疾病髮生層麵存在明顯相關關繫,兩者併髮時會對海馬膽堿代謝異常產生交互促進作用.
목적 연구뇌졸중후억욱(PSD)환자화뇌졸중후인지공능손해(PSCI)환자적경질자자공진파보(1H-MRS)표현,탐토뇌졸중후억욱화인지공능손해지간적관계.방법 련속선취무한대학중남의원2012년1월지2012년12월급성뇌졸중환자82명,근거근거중국정신질병분류방안여진단표준제3판화혈관성인지공능손해적전가공식장환자분위합병유인지공능손해적PSD조(A조)19례,PSD조(B조)21례,PSCI조(C조)22례,화몰유억욱화인지공능손해적대조조(D조)20례,분별재졸중발병일월이내급여1 H-MRS검사,대각조결과진행통계분석.결과 몰유발현PSD화PSCI지간유명현적상호관계.동시환유PSD화PSCI적환자해마Cho/Cr비치[좌측(1.05±0.10),우측(1.18±0.15)],고우기타각조[B조좌측(0.84±0.10),우측(0.88±0.08)；C조좌측(0.88±0.08)우측(0.87±0.07)；D조좌측(0.87±0.06),우측(0.89±0.06)],차이유통계학의의(P＜0.05).PSD화PSCI도가사해마Cho/Cr비치승고,차유교호촉진작용.결론 미발현PSD화PSCI재질병발생층면존재명현상관관계,량자병발시회대해마담감대사이상산생교호촉진작용.
Objective To investigate the relationship between Post stroke depression (PSD) and Post stroke cognitive impairment (PSCI) using proton magnetic resonance spectroscopy.Methods 82 patients of acute stroke,which were met with the third edition of the Chinese Classification of Mental Disorders (CCMD-Ⅲ) and expert consensus of cognitive impairment since January 2012 to December 2012,Select continuously 82 patients who are hospitalized in our hospital due to acute stroke from January 2012 to December 2012 from Zhongnan Hospital of Wuhan University,were examined by 1H-MRS in one month.They were divided into PSD and PSCI simultaneously (n =19),PSD (n =21),PSCI (n =22) and control group (n =20).Results The differences between PSD and PSCI was not significant.On hippocampus japonicas,the Cho/Cr ratio in patients of A group (left (1.05 ± 0.10),right(1.18 ± 0.15)),showed higher than those in B group (left (0.84 ± 0.10),right (0.88 ± 0.08)),C group (left(0.88 ±0.08),right (0.87 ±0.07)),D group(left(0.87 ±0.06),right(0.89 ±0.06)).The difference was statistically significant.PSD and PSCI promoted each other in influencing Cho/Cr ratio.Conclusion There is no significant relationship between PSD and PSCI in the produce of disease,and they can promote each other in hippocampus japonicas Cho/Cr ratio.
