CAJ | 학술논문

目的：分析替莫唑胺联合放疗在恶性脑胶质瘤产生的临床效果。方法：随机选取我院收治的恶性脑胶质瘤患者40例分为2组，每组20例；对照组进行单纯放疗，观察组在对照组的基础上添加替莫唑胺化疗。分析2组患者的临床效果比较。结果：观察组中7例完全缓解，10例部分缓解，2例病变稳定，仅有1例病变进展，高达95％的总有效率。对照组中5例完全缓解，8例部分缓解，3例病变稳定，4例病变进展，有80％的总有效率。观察组优于对照组， p＜0．05，则其差异具有统计学意义。结论：采用替莫唑胺联合放疗治疗恶性脑胶质瘤具有良好的临床疗效，不良反应低，有效率高，操作简便等，能够提高患者生存质量，值得在临床上应用推广。
목적：분석체막서알연합방료재악성뇌효질류산생적림상효과。방법：수궤선취아원수치적악성뇌효질류환자40례분위2조，매조20례；대조조진행단순방료，관찰조재대조조적기출상첨가체막서알화료。분석2조환자적림상효과비교。결과：관찰조중7례완전완해，10례부분완해，2례병변은정，부유1례병변진전，고체95％적총유효솔。대조조중5례완전완해，8례부분완해，3례병변은정，4례병변진전，유80％적총유효솔。관찰조우우대조조， p＜0．05，칙기차이구유통계학의의。결론：채용체막서알연합방료치료악성뇌효질류구유량호적림상료효，불량반응저，유효솔고，조작간편등，능구제고환자생존질량，치득재림상상응용추엄。
Objective:To analyze the clinical effect of Temozolomide Combined with radiotherapy for brain malignant gliomas produced . Methods:40 patients with malignant gliomas were randomly selected from our hospital patients , divided into two groups , 20 patients in each group;the control group only radiotherapy , observation group were based on the addition of temozolomide chemotherapy for brain malignant gliomas.To compare the clinical effect of two groups were analyzed .Results:The observation group of 7 cases were complete remission , 10 cases partial remission , 2 cases stable disease , and only 1 cases progression disease , the total effective up to 95%.Control group:5 cases were complete remission , 8 cases partial remission , 3 cases stable disease , 4 cases progression disease , the total effective 80%.The obser-vation group than in the control group , p<0.05, the difference has statistical significance .Conclusion:The use of Temozolomide Com-bined with radiotherapy for brain malignant gliomas might have good clinical curative effect treatment , low adverse reaction , high efficiency , simple operation, could improve the quality of life of patients , might be worthy of application and promotion in clinical .