中国伤残医学
中國傷殘醫學
중국상잔의학
CHINESE JOURNAL OF TRAUMA AND DISABILITY MEDICINE
2014年
18期
11-12
,共2页
毛明%周桂龙%韩静%黄二江%胡祥益
毛明%週桂龍%韓靜%黃二江%鬍祥益
모명%주계룡%한정%황이강%호상익
老年%口腔溃疡%血清%肿瘤坏死因子-α%病理学
老年%口腔潰瘍%血清%腫瘤壞死因子-α%病理學
노년%구강궤양%혈청%종류배사인자-α%병이학
Elderly%Oral ulcer%Serum%Tumor necrosis factor -α( TNF-α)%Pathology
目的：研究老年口腔溃疡患者血清肿瘤坏死因子（ TNF-α）变化并讨论其临床意义。方法：老年口腔溃疡患者102例，年龄69．1±11．6岁。选择体检健康人26例作正常对照，年龄66．3±6．4岁。血清TNF-α含量用双抗体夹心ELISA法测定，8例重型患者进行病理组织学检查。结果：老年口腔溃疡血清TNF-α含量（g/L）明显高于正常对照（46．1±11．7 vs 25．3±10．4，P＜0．01），重型（n＝14，53．7±19．1，P＜0．01）和中型（n＝53，43．1±10．5， P＜0．01）明显高于轻型（n＝35，34．1±9．6，P＜0．01），即重型TNF-α含量＞中型＞轻型。8例组织病理学检查包括5例是淋巴细胞、浆细胞和单核巨噬细胞浸润的炎症，3例是炎症伴有增生。结论：老年口腔溃疡血清TNF-α含量可明显增高，病变越重增加越明显，且病理改变是炎症或伴增生，疾病发生发展与TNF-α变化有关。
目的：研究老年口腔潰瘍患者血清腫瘤壞死因子（ TNF-α）變化併討論其臨床意義。方法：老年口腔潰瘍患者102例，年齡69．1±11．6歲。選擇體檢健康人26例作正常對照，年齡66．3±6．4歲。血清TNF-α含量用雙抗體夾心ELISA法測定，8例重型患者進行病理組織學檢查。結果：老年口腔潰瘍血清TNF-α含量（g/L）明顯高于正常對照（46．1±11．7 vs 25．3±10．4，P＜0．01），重型（n＝14，53．7±19．1，P＜0．01）和中型（n＝53，43．1±10．5， P＜0．01）明顯高于輕型（n＝35，34．1±9．6，P＜0．01），即重型TNF-α含量＞中型＞輕型。8例組織病理學檢查包括5例是淋巴細胞、漿細胞和單覈巨噬細胞浸潤的炎癥，3例是炎癥伴有增生。結論：老年口腔潰瘍血清TNF-α含量可明顯增高，病變越重增加越明顯，且病理改變是炎癥或伴增生，疾病髮生髮展與TNF-α變化有關。
목적：연구노년구강궤양환자혈청종류배사인자（ TNF-α）변화병토론기림상의의。방법：노년구강궤양환자102례，년령69．1±11．6세。선택체검건강인26례작정상대조，년령66．3±6．4세。혈청TNF-α함량용쌍항체협심ELISA법측정，8례중형환자진행병리조직학검사。결과：노년구강궤양혈청TNF-α함량（g/L）명현고우정상대조（46．1±11．7 vs 25．3±10．4，P＜0．01），중형（n＝14，53．7±19．1，P＜0．01）화중형（n＝53，43．1±10．5， P＜0．01）명현고우경형（n＝35，34．1±9．6，P＜0．01），즉중형TNF-α함량＞중형＞경형。8례조직병이학검사포괄5례시림파세포、장세포화단핵거서세포침윤적염증，3례시염증반유증생。결론：노년구강궤양혈청TNF-α함량가명현증고，병변월중증가월명현，차병리개변시염증혹반증생，질병발생발전여TNF-α변화유관。
Objective:To investigate the change of tumor necrosis factor -α( TNF-α) and histopathology in elderly patients with oral ulcer, and discuss its clinical significance .Methods:102 elderly patients with oral ulcer were tested , and their age was 69.1 ±11.6 years old.A medical healthy 26 cases were selected as normal control , (66.3 ±6.4 years old).Serums TNF-αlevels were determined by double antibody ELISA , and 8 severe patients were examined by pathological histology .Results: In the patients with oral ulcer , serum TNF-αlevels (? g/L) were significantly higher than normal controls (46.1 ±11.7 vs 25.3 ±10.4, P<0.01).The TNF-αlevels in severe (n=14,53.7 ±19.1, P<0.01) and moderate (n=53, 43.1 ±10.5, P<0.01) patients were significantly higher than those of mild (n=35,34.1 ±9.6, P<0.01), and the severe patients>moderate>mild in TNF-αlevels.Eight patients with pathological his-tology are inflammation including lymphocytes , plasma cells and mononuclear macrophage infiltration in 5 cases, and inflammation associ-ated with proliferation in 3 cases.Conclusion:The results showed that serum TNF -αlevel can obviously heighten in elderly patients with oral ulcer , and its pathological changes should be inflammation or with hyperplasia , and TNF-αcan involve the development process in the oral ulcer .
