国际皮肤性病学杂志
國際皮膚性病學雜誌
국제피부성병학잡지
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
2014年
4期
234-236
,共3页
银屑病%色素上皮衍生因子%血管内皮生长因子类
銀屑病%色素上皮衍生因子%血管內皮生長因子類
은설병%색소상피연생인자%혈관내피생장인자류
Psoriasis%Pigment epithelium-derived factor%Vascular endothelial growth factors
色素上皮衍生因子具有神经保护、抑制血管新生、抗肿瘤、抗炎、抗氧化等多种功能,成为肿瘤及血管新生、炎症性相关疾病治疗的新靶点.银屑病是慢性炎症性疾病并伴有异常血管新生,色素上皮衍生因子作为有效的血管生长抑制因子,在银屑病的研究中也逐渐受到关注.然而,色素上皮衍生因子在银屑病发病机制中的作用尚未明确.进一步探讨色素上皮衍生因子在银屑病发病机制中的作用,有望为银屑病治疗提供新途径.
色素上皮衍生因子具有神經保護、抑製血管新生、抗腫瘤、抗炎、抗氧化等多種功能,成為腫瘤及血管新生、炎癥性相關疾病治療的新靶點.銀屑病是慢性炎癥性疾病併伴有異常血管新生,色素上皮衍生因子作為有效的血管生長抑製因子,在銀屑病的研究中也逐漸受到關註.然而,色素上皮衍生因子在銀屑病髮病機製中的作用尚未明確.進一步探討色素上皮衍生因子在銀屑病髮病機製中的作用,有望為銀屑病治療提供新途徑.
색소상피연생인자구유신경보호、억제혈관신생、항종류、항염、항양화등다충공능,성위종류급혈관신생、염증성상관질병치료적신파점.은설병시만성염증성질병병반유이상혈관신생,색소상피연생인자작위유효적혈관생장억제인자,재은설병적연구중야축점수도관주.연이,색소상피연생인자재은설병발병궤제중적작용상미명학.진일보탐토색소상피연생인자재은설병발병궤제중적작용,유망위은설병치료제공신도경.
Pigment epithelium-derived factor (PEDF) has many activities,such as neuroprotective,anti-angiogenesis,anti-tumor,anti-inflammation,and antioxidant activities.It has become a novel target for the treatment of tumors,angiogenesis-and inflammation-related diseases.Since psoriasis is a chronic inflammatory skin disease associated with inappropriate angiogenesis,PEDF,as the most potent natural inhibitor of angiogenesis,has attracted more and more attention in the study of psoriasis.However,the role of PEDF in the pathogenesis of psoriasis is still unclear.To further clarify the role of PEDF in the pathogenesis of psoriasis may provide a novel treatment option for psoriasis.
