CAJ | 학술논문

目的：分析周围型肺腺癌在CT上的一些典型征象，并探讨这些征象与CD147、VEGF表达的关系。方法收集2006-01至2012-12周围型肺腺癌73例可作免疫组化的蜡块及术前 CT检查资料。采用免疫组化SP法分别测定肺腺癌组织中CD147及VEGF的表达结果，对阳性结果根据染色面积及染色强度进行等级划分。将CD147、VEGF的表达结果与术前CT检查的各特异性征象进行对比，观察两种基因表达结果与CT征象之间是否相关。结果 CD147表达与CT征象中的空泡征、肿块大小、棘突征、深分叶征、纵隔淋巴结转移之间有相关性（P＜0．05），与毛刺征、胸膜凹陷征无相关性（P＞0．05）；VEGF表达与毛刺征、棘突征、深分叶征、纵隔淋巴结转移之间有相关性（P＜0．05），与肿块大小、空泡征、胸膜凹陷征无相关性（P＞0．05）。结论肺腺癌的某些CT特异性征象与CD147、VEGF表达有相关性，可为判断肺腺癌的预后提供依据。
목적：분석주위형폐선암재CT상적일사전형정상，병탐토저사정상여CD147、VEGF표체적관계。방법수집2006-01지2012-12주위형폐선암73례가작면역조화적사괴급술전 CT검사자료。채용면역조화SP법분별측정폐선암조직중CD147급VEGF적표체결과，대양성결과근거염색면적급염색강도진행등급화분。장CD147、VEGF적표체결과여술전CT검사적각특이성정상진행대비，관찰량충기인표체결과여CT정상지간시부상관。결과 CD147표체여CT정상중적공포정、종괴대소、극돌정、심분협정、종격림파결전이지간유상관성（P＜0．05），여모자정、흉막요함정무상관성（P＞0．05）；VEGF표체여모자정、극돌정、심분협정、종격림파결전이지간유상관성（P＜0．05），여종괴대소、공포정、흉막요함정무상관성（P＞0．05）。결론폐선암적모사CT특이성정상여CD147、VEGF표체유상관성，가위판단폐선암적예후제공의거。
Objective To analyze the pathological mechanism of the typical features of lung adenocarcinoma in CT imaging ,and to study the relationship between the features and expression levels of CD 147 and VEGF.Methods In China-Japan Friendship Hospital and Air Force general Hospital , from 2006 to 2012, 73 cases of lung adenocarcinoma were pathologically confirmed .The wax block for immunohistochemistry and preoperative CT scan data were collected .Using immunohistochemical SP to detect the expression results of CD147 and VEGF in lung adenocarcinoma , positive results were graded according to size and staining intensity of staining .CT signs in-cluded spiculation, vacuole sign, spinal, tumor size, deep lobulation, pleural retraction and mediastinal lymph node metastasis .To com-pare and determine the relationship between the expressions of CD 147and VEGF and the features of lung adenocarcinoma CT imaging , and to observe whether there existed correlation between the expression of two genes results and CT signs .Results There was a correlation between the expression of CD147 and CT signs of the syndrome in vacuoles ,tumor size,spiculation sign,deep lobulation,mediastinal lymph node metastasis(P<0.05),no correlation with spiculation and pleural indentation (P>0.05).There was correlation between the expres-sion of VEGF and spiculation,spinal,deep lobulation, mediastinal lymph node metastasis (P<0.05),no correlation with tumor size,vac-uole sign,pleural indentation sign (P>0.05).Conclusions There is a correlation between some specific CT signs of adenocarcinoma of lung and the expression rate of CD 147 and VEGF.The research on the relationship of CD 147/VEGF expression and CT signs is helpful to further explore the development process of the tumor , more accurately judge the prognosis of lung adenocarcinoma .