CAJ | 학술논문

目的：研究中国汉族人群microRNA‐34b／c启动子区T＞C（rs4938723）多态性与肾细胞癌易感性之间的关系。方法采用病例对照研究模式，通过TaqMan探针PCR法检测年龄和性别匹配的710例中国汉族人群肾细胞癌患者和760例正常人群的microRNA‐34b／c启动子区T＞C（rs4938723）基因型，探讨该位点基因多态性与肾细胞癌易感性之间的关系。结果与 TT／TC基因型携带者相比，CC型（OR＝1．53，95％ CI＝1．06～2．21，CC基因型比TT基因型；OR＝1．48，95％ CI＝1．05～2．10，CC基因型比T T／TC基因型）携带者发生肾细胞癌的危险性明显升高。分层分析显示携带CC基因型的老年患者（OR＝1．80，95％CI＝1．08～3．01）、男性患者（OR＝1．64，95％ CI＝1．08～2．51）、吸烟患者（OR＝2．07，95％ CI＝1．16～3．69）及饮酒患者（OR＝1．94，95％ CI＝1．01～3．73）发生肾细胞癌的危险性明显升高。结论 microRNA‐34b／c启动子区T＞C（rs4938723）基因多态性与我国汉族人群肾细胞癌易感性有关，CC型携带者发生肾细胞癌的危险性要明显高于T T／TC型携带者。
목적：연구중국한족인군microRNA‐34b／c계동자구T＞C（rs4938723）다태성여신세포암역감성지간적관계。방법채용병례대조연구모식，통과TaqMan탐침PCR법검측년령화성별필배적710례중국한족인군신세포암환자화760례정상인군적microRNA‐34b／c계동자구T＞C（rs4938723）기인형，탐토해위점기인다태성여신세포암역감성지간적관계。결과여 TT／TC기인형휴대자상비，CC형（OR＝1．53，95％ CI＝1．06～2．21，CC기인형비TT기인형；OR＝1．48，95％ CI＝1．05～2．10，CC기인형비T T／TC기인형）휴대자발생신세포암적위험성명현승고。분층분석현시휴대CC기인형적노년환자（OR＝1．80，95％CI＝1．08～3．01）、남성환자（OR＝1．64，95％ CI＝1．08～2．51）、흡연환자（OR＝2．07，95％ CI＝1．16～3．69）급음주환자（OR＝1．94，95％ CI＝1．01～3．73）발생신세포암적위험성명현승고。결론 microRNA‐34b／c계동자구T＞C（rs4938723）기인다태성여아국한족인군신세포암역감성유관，CC형휴대자발생신세포암적위험성요명현고우T T／TC형휴대자。
ABSTRACT:Objective To evaluate the relationship between the microRNA‐34b/c promoter region T>C (rs4938723) pol‐ymorphism and renal cell carcinoma risk (RCC ) in southern Han ethnic Chinese population .Methods The rs4938723 was genotyped using TaqMan method to explore the relationship between this polymorphism and the risk of RCC in a case‐control study of 710 RCC patients and 760 control subjects .Results Individuals carrying the CC genotype had a significantly in‐creased RCC risk [odds ratio (OR)=1 .53 ,95% confidence interval (CI)=1 .06~2 .21 for CC vs .TT ,and OR=1 .48 ,95%CI=1 .05~2 .10 for CC vs .TT/TC ,respectively] compared with those with TT or TT/TC genotypes .Furthermore ,the in‐creased risk was more evident in the subgroups of older subjects (OR=1 .80 ,95% CI=1 .08~3 .01) ,males (OR=1 .64 ,95%CI=1 .08~2 .51) ,smokers (OR=2 .07 ,95% CI=1 .16~3 .69) and drinkers (OR=1 .94 ,95% CI=1 .01~3 .73) .Conclu‐sion These results suggest that the microRNA‐34b/c rs4938723 C allele may increase the susceptibility to RCC by decreasing the activity of microRNA‐34b/c promoter compared with T allele .