现代泌尿外科杂志
現代泌尿外科雜誌
현대비뇨외과잡지
JOURNAL OF MODERN UROLOGY
2014年
11期
719-723
,共5页
包卿兵%何国华%张长庚%杨程
包卿兵%何國華%張長庚%楊程
포경병%하국화%장장경%양정
良性前列腺增生%C反应蛋白%膀胱出口梗阻%下尿路症状%国际前列腺症状评分
良性前列腺增生%C反應蛋白%膀胱齣口梗阻%下尿路癥狀%國際前列腺癥狀評分
량성전렬선증생%C반응단백%방광출구경조%하뇨로증상%국제전렬선증상평분
benign prostatic hyperplasia%C-reactive protein%bladder outlet obstruction%lower urinary tract symptoms%International Prostate Symptom Score
目的：探讨前列腺增生患者血C反应蛋白（CRP）与下尿路症状的关系。方法共141例在我院就诊的前列腺增生并有下尿路症状患者，所有患者行IPSS评分、体格检查、最大尿流率测定、尿量、残余尿、前列腺体积、血PSA和CRP测定。计算排尿期评分（IPSS‐V ）与储尿期评分（IPSS‐S ）的比值（用IPSS‐V／S表示），当IPSS‐V／S≥1时给予患者α‐受体阻断剂口服，当IPSS‐V／S＜1时给予患者抗毒蕈碱剂口服。比较血CRP水平与各参数之间的关系及服药后各参数的变化。结果所有患者平均血CRP值为（3．43±2．30）mg／L ，单因素相关分析提示血CRP与年龄、PSA、排尿量相关，与残余尿、前列腺体积无关，与总IPSS、IPSS‐S正相关，与IPSS‐V／S负相关。多因素分析血CRP与年龄、总IPSS和IPSS‐S相关。IPSS‐V／S＜1患者给予托特罗定治疗3月后血CRP明显下降。结论前列腺增生患者血CRP与储尿期症状及膀胱功能障碍相关，表明慢性炎症是储尿期症状为主的下尿路症状的原因之一。
目的：探討前列腺增生患者血C反應蛋白（CRP）與下尿路癥狀的關繫。方法共141例在我院就診的前列腺增生併有下尿路癥狀患者，所有患者行IPSS評分、體格檢查、最大尿流率測定、尿量、殘餘尿、前列腺體積、血PSA和CRP測定。計算排尿期評分（IPSS‐V ）與儲尿期評分（IPSS‐S ）的比值（用IPSS‐V／S錶示），噹IPSS‐V／S≥1時給予患者α‐受體阻斷劑口服，噹IPSS‐V／S＜1時給予患者抗毒蕈堿劑口服。比較血CRP水平與各參數之間的關繫及服藥後各參數的變化。結果所有患者平均血CRP值為（3．43±2．30）mg／L ，單因素相關分析提示血CRP與年齡、PSA、排尿量相關，與殘餘尿、前列腺體積無關，與總IPSS、IPSS‐S正相關，與IPSS‐V／S負相關。多因素分析血CRP與年齡、總IPSS和IPSS‐S相關。IPSS‐V／S＜1患者給予託特囉定治療3月後血CRP明顯下降。結論前列腺增生患者血CRP與儲尿期癥狀及膀胱功能障礙相關，錶明慢性炎癥是儲尿期癥狀為主的下尿路癥狀的原因之一。
목적：탐토전렬선증생환자혈C반응단백（CRP）여하뇨로증상적관계。방법공141례재아원취진적전렬선증생병유하뇨로증상환자，소유환자행IPSS평분、체격검사、최대뇨류솔측정、뇨량、잔여뇨、전렬선체적、혈PSA화CRP측정。계산배뇨기평분（IPSS‐V ）여저뇨기평분（IPSS‐S ）적비치（용IPSS‐V／S표시），당IPSS‐V／S≥1시급여환자α‐수체조단제구복，당IPSS‐V／S＜1시급여환자항독심감제구복。비교혈CRP수평여각삼수지간적관계급복약후각삼수적변화。결과소유환자평균혈CRP치위（3．43±2．30）mg／L ，단인소상관분석제시혈CRP여년령、PSA、배뇨량상관，여잔여뇨、전렬선체적무관，여총IPSS、IPSS‐S정상관，여IPSS‐V／S부상관。다인소분석혈CRP여년령、총IPSS화IPSS‐S상관。IPSS‐V／S＜1환자급여탁특라정치료3월후혈CRP명현하강。결론전렬선증생환자혈CRP여저뇨기증상급방광공능장애상관，표명만성염증시저뇨기증상위주적하뇨로증상적원인지일。
ABSTRACT:Objective To investigate the association between serum C‐reactive protein (CRP) level in men with benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) .Methods A total of 141 men with BPH and LUTS were enrolled .All patients completed the International Prostate Symptoms Score (IPSS) and urological examinations .The pa‐rameters of maximum flow rate (Qmax) ,voided volume ,post‐void residual ,prostate volume ,serum prostate specific antigen (PSA) and serum CRP levels were obtained .All patients were treated with alpha‐blocker or antimuscarinic agent based on the IPSS voiding to storage subscore ratio (IPSS‐V/S) .Correlation analyses were performed between serum CRP levels with age , IPSS ,TPV ,Qmax ,PVR ,VV ,PSA and between baseline and post treatment .Results The mean serum CRP level was (3.43 ± 2 .30)mg/L .Univariate analyses revealed serum CRP levels were significantly associated with age (P<0 .001) ,PSA levels (P<0 .05) and voided volume (P<0 .05) ,but not with post‐void residual or prostate volume (P>0 .05) .CRP levels were positively associated with total IPSS (P<0 .05) and storage IPSS (P<0 .001) ,and negatively associated with IPSS‐V/S ( P<0.001) .Multivariate analyses revealed that serum CRP levels were significantly associated with age (P<0 .05) ,total IPSS and storage IPSS subscore (P<0 .001) .Patients with IPSS‐V/S<1 and treated with tolterodine for 3 months had significant decrease of CRP levels after treatment .Conclusion Serum CRP levels are associated with storage LUTS and sensory bladder disorders ,suggesting chronic inflammation might play a role in patients with storage predominant LUTS .
