内蒙古民族大学学报（自然科学版）
內矇古民族大學學報（自然科學版）
내몽고민족대학학보（자연과학판）
JOURNAL OF INNER MONGOLIA UNIVERSITY FOR NATIONALITIES(NATURAL SCIENCES)
2014年
5期
579-581
,共3页
蒙成药%壮西小灰剂%胃溃疡%动物模型%药理作用
矇成藥%壯西小灰劑%胃潰瘍%動物模型%藥理作用
몽성약%장서소회제%위궤양%동물모형%약리작용
Mongolian medicine%Zhuangxixiaohuiji%Gastric ulcer%Animal model%Pharmacological effect
目的：通过大鼠胃溃疡动物模型的治疗，观察蒙成药壮西小灰剂治疗胃溃疡的作用及机制.方法：取Wistar大鼠60只，体重180~220g，雌雄各半，按体重随机分为空白组、模型组、壮西小灰剂小剂量组、壮西小灰剂中剂量组、壮西小灰剂大剂量组、阳性组等六个组，每组10只大鼠.制模次日起空白组和模型组均按2ml/100g比例给生理盐水，治疗组壮西小灰剂小、中、大剂量组分别按0.25g/kg、0.5g/kg、1g/kg比例给壮西小灰剂混悬液，阳性组按0.4g/kg比例给枸橼酸铋钾混悬液，每日两次（上下午各一次），连续给药15天.观察实验大鼠的胃液量、胃酸总量、胃蛋白酶等的变化.结果：给药组胃液量、胃液总酸度及胃蛋白酶活性较模型组比较，（1）空白组、壮西小灰剂小、中剂量组能显著减少胃液分泌量（P<0.01）；壮西小灰剂大剂量组也能减少胃液分泌量（P<0.05）；（2）空白组的胃液总酸度明显减低（P<0.01），壮西小灰剂小、中、大剂量组的胃液总酸度也减低（P<0.05）；（3）与壮西小灰剂大剂量组比较，空白组和壮西小灰剂中剂量组能减少胃液分泌量（P<0.05）.壮西小灰剂中剂量组和阳性组能降低胃蛋白酶活性（P<0.05）；（4）与阳性组比较，空白组和壮西小灰剂小剂量组能显著减少胃液分泌量（P<0.01），壮西小灰剂中剂量组也能减少胃液分泌量（P<0.05）.结论：蒙成药壮西小灰剂具有明显抑制胃液分泌，减少胃酸及胃蛋白酶的作用.
目的：通過大鼠胃潰瘍動物模型的治療，觀察矇成藥壯西小灰劑治療胃潰瘍的作用及機製.方法：取Wistar大鼠60隻，體重180~220g，雌雄各半，按體重隨機分為空白組、模型組、壯西小灰劑小劑量組、壯西小灰劑中劑量組、壯西小灰劑大劑量組、暘性組等六箇組，每組10隻大鼠.製模次日起空白組和模型組均按2ml/100g比例給生理鹽水，治療組壯西小灰劑小、中、大劑量組分彆按0.25g/kg、0.5g/kg、1g/kg比例給壯西小灰劑混懸液，暘性組按0.4g/kg比例給枸櫞痠鉍鉀混懸液，每日兩次（上下午各一次），連續給藥15天.觀察實驗大鼠的胃液量、胃痠總量、胃蛋白酶等的變化.結果：給藥組胃液量、胃液總痠度及胃蛋白酶活性較模型組比較，（1）空白組、壯西小灰劑小、中劑量組能顯著減少胃液分泌量（P<0.01）；壯西小灰劑大劑量組也能減少胃液分泌量（P<0.05）；（2）空白組的胃液總痠度明顯減低（P<0.01），壯西小灰劑小、中、大劑量組的胃液總痠度也減低（P<0.05）；（3）與壯西小灰劑大劑量組比較，空白組和壯西小灰劑中劑量組能減少胃液分泌量（P<0.05）.壯西小灰劑中劑量組和暘性組能降低胃蛋白酶活性（P<0.05）；（4）與暘性組比較，空白組和壯西小灰劑小劑量組能顯著減少胃液分泌量（P<0.01），壯西小灰劑中劑量組也能減少胃液分泌量（P<0.05）.結論：矇成藥壯西小灰劑具有明顯抑製胃液分泌，減少胃痠及胃蛋白酶的作用.
목적：통과대서위궤양동물모형적치료，관찰몽성약장서소회제치료위궤양적작용급궤제.방법：취Wistar대서60지，체중180~220g，자웅각반，안체중수궤분위공백조、모형조、장서소회제소제량조、장서소회제중제량조、장서소회제대제량조、양성조등륙개조，매조10지대서.제모차일기공백조화모형조균안2ml/100g비례급생리염수，치료조장서소회제소、중、대제량조분별안0.25g/kg、0.5g/kg、1g/kg비례급장서소회제혼현액，양성조안0.4g/kg비례급구연산필갑혼현액，매일량차（상하오각일차），련속급약15천.관찰실험대서적위액량、위산총량、위단백매등적변화.결과：급약조위액량、위액총산도급위단백매활성교모형조비교，（1）공백조、장서소회제소、중제량조능현저감소위액분비량（P<0.01）；장서소회제대제량조야능감소위액분비량（P<0.05）；（2）공백조적위액총산도명현감저（P<0.01），장서소회제소、중、대제량조적위액총산도야감저（P<0.05）；（3）여장서소회제대제량조비교，공백조화장서소회제중제량조능감소위액분비량（P<0.05）.장서소회제중제량조화양성조능강저위단백매활성（P<0.05）；（4）여양성조비교，공백조화장서소회제소제량조능현저감소위액분비량（P<0.01），장서소회제중제량조야능감소위액분비량（P<0.05）.결론：몽성약장서소회제구유명현억제위액분비，감소위산급위단백매적작용.
Objective:Through treating rat gastric ulcer animal model, to investigate the function of Zhuangxixiaohuiji in the treatment of gastric ulcer and its mechanism. Methods:60 Wistar rats weighing 180-220g, half male and half female, were randomly divided into control group, model group, Zhuangxixiaohuiji low-dose group, middle-dose group, high-dose group, positive group totally six groups, 10 rats in each group. The next day after molding, the blank group and the model group were treated with normal saline according to the proportion of 2ml/100g. Zhuangxixiaohuiji low-dose group, mid-dle-dose group and high-dose group were given Zhuangxixiaohuiji suspensions according to the proportion of 0.25g/kg, 0.5g/kg and 1g/kg respectively. The positive group was treated with Bismuth potassium citrate mixed suspension according to the proportion of 0.4g/kg, twice daily(morning and afternoon each time), consecutively treated for 15 days. The changes of rat gastric juice volume, gastric acid amount, pepsin and so on were observed. Results:The juice volume, total acidity of gastric juice and pepsin activity of the treatment group compared with the model group,①the gastric juice secretion volume in the control group, Zhuangxixiaohuiji low-dose group and middle-dose group were significantly reduced(P<0.01);in the Zhuangxixiaohuiji high-dose group was also reduced(P<0.05).②The total acidity of gastric juice in the blank group <br> was significantly reduced(P<0.01), in the Zhuangxixiaohuiji low-dose group, middle-dose group and high-dose group were all reduced(P<0.05).③Compared with Zhuangxixiaohuiji high-dose group, the gastric secretion volume in the control group and the Zhuangxixiaohuiji middle-dose group were reduced(P<0.05). The pepsin activity in the Zhuangxixiaohuiji middle-dose group and the positive group were reduced(P<0.05).④Compared with the positive group, the gastric secretion volume in the control group and the Zhuangxixiaohuiji low-dose group were significantly reduced (P<0.01), in the Zhuangxixiaohuiji middle-dose group were also reduced(P<0.05). Conclusion:Mongolian medicine Zhuangxixiaohuiji has significant effects on inhibiting gastric secretion, reducing gastric acid and pepsin activity.
