CAJ | 학술논문

目的：研究橙皮苷在碱性溶液中的稳定性，为其提取、纯化工艺的质量控制以及制剂产品的开发提供实验依据。方法：采用RP-HPLC法测定不同温度、pH、加热时间下橙皮苷的含量变化。结果：加热条件下橙皮苷碱性溶液发生了降解，含量随加热温度的升高和加热时间的延长，呈不断下降趋势；弱碱条件下较稳定。结论：为保证溶液中橙皮苷的稳定，在生产过程中应使溶液处于低温（50℃以下）及弱碱条件下，并尽量减少溶液的受热时间。
목적：연구등피감재감성용액중적은정성，위기제취、순화공예적질량공제이급제제산품적개발제공실험의거。방법：채용RP-HPLC법측정불동온도、pH、가열시간하등피감적함량변화。결과：가열조건하등피감감성용액발생료강해，함량수가열온도적승고화가열시간적연장，정불단하강추세；약감조건하교은정。결론：위보증용액중등피감적은정，재생산과정중응사용액처우저온（50℃이하）급약감조건하，병진량감소용액적수열시간。
This article was aimed to study the stability of hesperidin in alkaline solution, in order to provide experi-ment evidences for quality control of extraction and purification as well as formulation development. RP-HPLC was applied to determinate content changes of hesperidin in alkaline solution by changing the temperature, pH and heat-ing time. The results showed that hesperidin was degraded in alkaline solution by heating. The content of hesperidin decreased along with the increasing of heating temperature and heating time. The hesperidin appeared to be more stable in a weak base. It was concluded that for the purpose of ensuring of the stability of hesperidin in alkaline so-lution, it should be kept at low temperature (below 50℃), weak base conditions and shorten the heating time during the preparation process.