CAJ | 학술논문

大量证据表明γ-氨基丁酸（GABA）能系统在神经精神疾病的病理过程中起重要作用。A型γ-氨基丁酸（GABAA）受体调节剂在临床上的应用已经有较长历史，但副作用和药物依赖的风险限制了它们的使用。随着对不同GABAA受体亚型在这些疾病病理过程中所起作用的不断深入了解，亚型选择性GABAA受体调节剂被认为可能是潜在的治疗策略。本文回顾了揭示GABAA受体和焦虑、抑郁及精神分裂症之间联系的研究成果，同时对亚型选择性GABAA受体调节剂的研究进展作一综述。
대량증거표명γ-안기정산（GABA）능계통재신경정신질병적병리과정중기중요작용。A형γ-안기정산（GABAA）수체조절제재림상상적응용이경유교장역사，단부작용화약물의뢰적풍험한제료타문적사용。수착대불동GABAA수체아형재저사질병병리과정중소기작용적불단심입료해，아형선택성GABAA수체조절제피인위가능시잠재적치료책략。본문회고료게시GABAA수체화초필、억욱급정신분렬증지간련계적연구성과，동시대아형선택성GABAA수체조절제적연구진전작일종술。
Abundant evidences indicate a role of GABAergic system in the pathogenesis of neuropsychiatric dis-orders. GABAA receptors modulators have been long used in clinical. But the unwanted side-effect and risk of drug dependence have limited their use. With the increase understanding of the role of individual GABAA recep-tor subtypes in the pathology of these diseases, the subtype-selective GABAA receptors modulators and the multi-compound therapy may serve as potential therapeutic strategies. Here we review the researches which revealed the involvement of GABAA receptors in anxiety, depression and schizophrenia, and the research for new development in subtype-selective GABAA receptor modulators.