世界科学技术-中医药现代化
世界科學技術-中醫藥現代化
세계과학기술-중의약현대화
WORLD SCIENCE AND TECHNOLOGY-MODERNIZATION OF TRADITIONAL CHINESE MEDICINE
2014年
10期
2157-2161
,共5页
益气温阳%活血利水%IR%心肌组织病理学改变
益氣溫暘%活血利水%IR%心肌組織病理學改變
익기온양%활혈이수%IR%심기조직병이학개변
Yi-Qi Wen-Yang%Huo-Xue Li-Shui%IR%pathological change of myocardium
目的：探讨益气温阳、活血利水方药对充血性心力衰竭（CHF）大鼠模型胰岛素抵抗（IR）及心肌组织病理学改变的影响。方法：通过对Wistar雄性大鼠尾静脉注射盐酸阿霉素制备充血性心力衰竭大鼠模型，造模成功后将Wistar雄性大鼠随机分成模型组、西药组、方药低剂量组、方药中剂量组、方药高剂量组，连续灌胃4周后，取内眦静脉窦静脉血3 mL，测血糖及血清胰岛素，计算IR。最后处死大鼠，取出心脏，切片HE染色，观察心肌组织病理学改变。结果：与模型组比较，益气温阳、活血利水方药能明显改善CHF大鼠IR水平（P<0.05），其中高、中剂量组较为明显；同时益气温阳、活血利水方药能改善CHF大鼠心肌细胞的损伤，高剂量组心肌细胞形态学的改变接近地高辛组。结论：益气温阳、活血利水方药能一定程度逆转大鼠CHF的IR并改善心室重构。
目的：探討益氣溫暘、活血利水方藥對充血性心力衰竭（CHF）大鼠模型胰島素牴抗（IR）及心肌組織病理學改變的影響。方法：通過對Wistar雄性大鼠尾靜脈註射鹽痠阿黴素製備充血性心力衰竭大鼠模型，造模成功後將Wistar雄性大鼠隨機分成模型組、西藥組、方藥低劑量組、方藥中劑量組、方藥高劑量組，連續灌胃4週後，取內眥靜脈竇靜脈血3 mL，測血糖及血清胰島素，計算IR。最後處死大鼠，取齣心髒，切片HE染色，觀察心肌組織病理學改變。結果：與模型組比較，益氣溫暘、活血利水方藥能明顯改善CHF大鼠IR水平（P<0.05），其中高、中劑量組較為明顯；同時益氣溫暘、活血利水方藥能改善CHF大鼠心肌細胞的損傷，高劑量組心肌細胞形態學的改變接近地高辛組。結論：益氣溫暘、活血利水方藥能一定程度逆轉大鼠CHF的IR併改善心室重構。
목적：탐토익기온양、활혈이수방약대충혈성심력쇠갈（CHF）대서모형이도소저항（IR）급심기조직병이학개변적영향。방법：통과대Wistar웅성대서미정맥주사염산아매소제비충혈성심력쇠갈대서모형，조모성공후장Wistar웅성대서수궤분성모형조、서약조、방약저제량조、방약중제량조、방약고제량조，련속관위4주후，취내자정맥두정맥혈3 mL，측혈당급혈청이도소，계산IR。최후처사대서，취출심장，절편HE염색，관찰심기조직병이학개변。결과：여모형조비교，익기온양、활혈이수방약능명현개선CHF대서IR수평（P<0.05），기중고、중제량조교위명현；동시익기온양、활혈이수방약능개선CHF대서심기세포적손상，고제량조심기세포형태학적개변접근지고신조。결론：익기온양、활혈이수방약능일정정도역전대서CHF적IR병개선심실중구。
This study was aimed to investigate the effect of Yi-Qi Wen-Yang (YQWY) and Huo-Xue Li-Shui (HXLS) decoction on changes of insulin resistance (IR) model and the myocardial tissues of rats with congestive heart failure (CHF) pathology. CHF rat models were established on Wistar male rats through injection of doxorubicin hydrochlo-ride into rat tail vein. Wistar male rats models were randomly divided into the model group, western medicine group, low dose decoction group, middle dose decoction group, and high dose decoction group. After 4-week gavage, 3 mL vein blood was taken from the angular vein sinus for the determination of blood glucose and serum insulin, and the calculation of IR. Finally, the rats were sacrificed. And then, the heart was removed to make HE slice and observe the pathological change of myocardium. The results showed that compared with the model group, YQWY and HXLS decoction can improve the IR level among CHF rats (P<0.05). Among them, the effects of the high dose and middle dose group were obvious. At the same time, this decoction can improve the myocardial cells in CHF rats in myocar-dial cells of the high dose group. And its morphology change was close to the digoxin group. It was concluded that YQWY and HXLS decoction can reverse IR and improve ventricular remodeling among CHF rats to a certain extent.
