中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2014年
21期
211-213
,共3页
单磷酸阿糖腺苷%阿昔洛韦分散片%带状疱疹%治疗
單燐痠阿糖腺苷%阿昔洛韋分散片%帶狀皰疹%治療
단린산아당선감%아석락위분산편%대상포진%치료
Vidarabine monophosphate%Aciclovir dispersible tablets%Herpes zoster%Treatment
目的：观察和评价单纯口服阿昔洛韦分散片以及联合静脉滴注单磷酸阿糖腺苷治疗带状疱疹的临床疗效。方法136例带状疱疹患者随机分为两组，治疗组75例，男39例，女36例，采用单磷酸阿糖腺苷0.2g,加入0.9%氯化钠250mL 静脉滴注，1次/d,口服阿昔洛韦分散片0.2g，5次/d，7d 为1疗程；对照组61例，男32例，女29例，单纯口服阿昔洛韦分散片0.2g，5次/d，共7d。于治疗前、后记录每天就诊时水疱面积，有无新发水疱及皮疹结痂数，疼痛减轻程度，脱痂的时间。结果治疗组和对照组的总有效率（治愈率+有效率）分别为93.33%和80.33%，两组差异有统计学意义（x2=4.081，P ＜0.05），治疗组止痛、结痂、脱痂时间均较对照组明显缩短（P ＜0.05）。结论静脉滴注单磷酸阿糖腺苷联合口服阿昔洛韦分散片治疗带状疱疹起效快，疗程短，能快速缓解疼痛，安全性好。
目的：觀察和評價單純口服阿昔洛韋分散片以及聯閤靜脈滴註單燐痠阿糖腺苷治療帶狀皰疹的臨床療效。方法136例帶狀皰疹患者隨機分為兩組，治療組75例，男39例，女36例，採用單燐痠阿糖腺苷0.2g,加入0.9%氯化鈉250mL 靜脈滴註，1次/d,口服阿昔洛韋分散片0.2g，5次/d，7d 為1療程；對照組61例，男32例，女29例，單純口服阿昔洛韋分散片0.2g，5次/d，共7d。于治療前、後記錄每天就診時水皰麵積，有無新髮水皰及皮疹結痂數，疼痛減輕程度，脫痂的時間。結果治療組和對照組的總有效率（治愈率+有效率）分彆為93.33%和80.33%，兩組差異有統計學意義（x2=4.081，P ＜0.05），治療組止痛、結痂、脫痂時間均較對照組明顯縮短（P ＜0.05）。結論靜脈滴註單燐痠阿糖腺苷聯閤口服阿昔洛韋分散片治療帶狀皰疹起效快，療程短，能快速緩解疼痛，安全性好。
목적：관찰화평개단순구복아석락위분산편이급연합정맥적주단린산아당선감치료대상포진적림상료효。방법136례대상포진환자수궤분위량조，치료조75례，남39례，녀36례，채용단린산아당선감0.2g,가입0.9%록화납250mL 정맥적주，1차/d,구복아석락위분산편0.2g，5차/d，7d 위1료정；대조조61례，남32례，녀29례，단순구복아석락위분산편0.2g，5차/d，공7d。우치료전、후기록매천취진시수포면적，유무신발수포급피진결가수，동통감경정도，탈가적시간。결과치료조화대조조적총유효솔（치유솔+유효솔）분별위93.33%화80.33%，량조차이유통계학의의（x2=4.081，P ＜0.05），치료조지통、결가、탈가시간균교대조조명현축단（P ＜0.05）。결론정맥적주단린산아당선감연합구복아석락위분산편치료대상포진기효쾌，료정단，능쾌속완해동통，안전성호。
Objective To investigate and evaluate the efficacy of Vidarabine monophosphate combined with acyclovir dispersible tablets in the treatment of herpes zoster. Methods 136 cases of herpes zoster patients were randomly divided into two groups. 75 cases in the treatment group, including male 39 cases and female 36 cases, were treated with Vidarabine monophosphate 0.2g, adding 0.9% sodium chloride 250ml intravenous drip, once a day, and oral aciclovir dispersion tablets 0.2g, 5 times a day, which were 7 days for a course of treatment. 61 cases of the control group, including male 32 cases, female 29 cases, were only treated with oral aciclovir dispersion tablets 0.2g, 5 times a day for 7 days. Before and after treatment, blister area, new blisters and scabbed rashes number, the degree of pain alleviation, and decrustation time were recorded daily. Results The total effective rate of treatment group and the control group were 93.33% and 80.33% respectively, there was significant difference between two groups (x2=4.081, P < 0.05). The time of relieve pain, the scab time, and scab off time were significantly shorter of the treatment group than those of the control group (P < 0.05). Conclusion Intravenous infusion of Vidarabine monophosphate combined with oral acyclovir dispersible tablets treatment of herpes zoster with rapid onset, short course of treatment, can quickly relieve pain, good safety.
