CAJ | 학술논문

目的：探讨血浆 BNP 检测在慢性心衰诊断及预后评估中的临床意义。方法回顾性分析慢性心力衰竭患者100例的临床资料，分析 BNP 水平与心功能分级、左室射血分数、左室舒张末期内径的关系。并根据BNP 水平分为＞400pg/mL 组和≤400pg/mL 组，比较两组患者房颤、陈旧性心肌梗死以及死亡率。结果随着心功能分级的升高，BNP 水平显著升高，LVEF 水平显著下降，LVEDD 显著增加（P ＜0.01）。BNP 与心功能分级和 LVEDD 呈正相关（r=0.921，0.917，P ＜0.01），与 LVEF 呈负相关（r=-0.960，P ＜0.01）。BNP水平＞400pg/mL 的患者房颤、陈旧性心梗的发生率及死亡率更高（P ＜0.05或＜0.01）。结论血浆 BNP水平检测能够反映慢性心衰患者左心室功能，对患者诊断、预后评估均具有重要的临床意义。
목적：탐토혈장 BNP 검측재만성심쇠진단급예후평고중적림상의의。방법회고성분석만성심력쇠갈환자100례적림상자료，분석 BNP 수평여심공능분급、좌실사혈분수、좌실서장말기내경적관계。병근거BNP 수평분위＞400pg/mL 조화≤400pg/mL 조，비교량조환자방전、진구성심기경사이급사망솔。결과수착심공능분급적승고，BNP 수평현저승고，LVEF 수평현저하강，LVEDD 현저증가（P ＜0.01）。BNP 여심공능분급화 LVEDD 정정상관（r=0.921，0.917，P ＜0.01），여 LVEF 정부상관（r=-0.960，P ＜0.01）。BNP수평＞400pg/mL 적환자방전、진구성심경적발생솔급사망솔경고（P ＜0.05혹＜0.01）。결론혈장 BNP수평검측능구반영만성심쇠환자좌심실공능，대환자진단、예후평고균구유중요적림상의의。
Objective To discuss Significance of BNP for diagnosis and prognosis in chronic heart failure. Methods Selected 100 cases with chronic heart failure were retrospectively studied. Relationships between BNP and NYHA, LVEF, LVEDD were analyzed. All patients were divided into > 400pg/mL group and ≤ 400pg/mL group according to BNP levels, and AF, old myocardial infarction and mortality rates were compared. Results With the increase of cardiac function, BNP levels were significantly increased, LVEF significantly decreased, and LVEDD significantly increased(P < 0.01). BNP showed a significant positive correlation with cardiac function and LVEDD (r=0.921,0.917,P < 0.01), and showed a significant negative correlation with LVEF(r= -0.960, P < 0.01). AF, old myocardial infarction and mortality rates in > 400pg/mL group were higher than ≤ 400pg/mL group(P < 0.05 or< 0.01). Conclusion Detection of plasma BNP levels reflects left ventricular function in patients with chronic heart failure, and has important clinical significance for diagnosis and prognosis.