CAJ | 학술논문

目的：探讨右美托咪定用于全身麻醉的临床效果。方法选取我院2011年5月～2013年5月期间收治的88例需要实施全身麻醉的患者，按照随机数字表法将其平均分成研究组与对照组两组，每组各44例，研究组采用右美托咪定辅助全身麻醉；对照组采用生理盐水辅助麻醉，比较两组在全身麻醉过程中患者 Ramsay 镇静评分、心跳、血压及使用异丙酚、芬太尼的剂量，不良反应率等。结果在给药5min 后，研究组 Ramsay 镇静评分稍高于对照组；在给予10min 后，研究组 Ramsay 镇静评分明显高于对照组，两组相比，差异有统计学意义（x2=6.13，P=0.002）。研究组在全身麻醉过程中用芬太尼、丙泊酚的剂量明显少于对照组，两组差异有统计学意义（t=5.54，P=0.02）；且两组的心率、血压相比，差异明显，有统计学意义（t=4.97，P=0.03）。但两组的气管插管、拔管前后所用时间、手术时间及术后清醒时间无明显差异，不具有统计学意义（P ＞0.05）。研究组与对照组均未发生肌肉颤动及躁动不安等相关不良反应症状。结论将右美托咪定用于全身麻醉，效果佳，安全系数高，且有明显的镇静功效，值得临床推广应用。
목적：탐토우미탁미정용우전신마취적림상효과。방법선취아원2011년5월～2013년5월기간수치적88례수요실시전신마취적환자，안조수궤수자표법장기평균분성연구조여대조조량조，매조각44례，연구조채용우미탁미정보조전신마취；대조조채용생리염수보조마취，비교량조재전신마취과정중환자 Ramsay 진정평분、심도、혈압급사용이병분、분태니적제량，불량반응솔등。결과재급약5min 후，연구조 Ramsay 진정평분초고우대조조；재급여10min 후，연구조 Ramsay 진정평분명현고우대조조，량조상비，차이유통계학의의（x2=6.13，P=0.002）。연구조재전신마취과정중용분태니、병박분적제량명현소우대조조，량조차이유통계학의의（t=5.54，P=0.02）；차량조적심솔、혈압상비，차이명현，유통계학의의（t=4.97，P=0.03）。단량조적기관삽관、발관전후소용시간、수술시간급술후청성시간무명현차이，불구유통계학의의（P ＞0.05）。연구조여대조조균미발생기육전동급조동불안등상관불량반응증상。결론장우미탁미정용우전신마취，효과가，안전계수고，차유명현적진정공효，치득림상추엄응용。
Objective To investigate the clinical effect of dexmedetomidine using for general anesthesia. Methods Selected 88 patients who need to implement general anesthesia in our hospital from May 2011 to May 2013, They were randomly divided into the study group and the control group, each group had 44 cases, the study group were given dexmedetomidine for assisted general anesthesia; the control group were given saline assisted anesthesia, then compared the two groups of patients in the process of Ramsay sedation score, heart rate, blood pressure, the dosage of propofol, fentanyl and the adverse reaction rate during general anesthesia. Results In 5 minutes after administration, the Ramsay sedation score of the research group was slightly higher than that of the control group; in 10 minutes after administration, the Ramsay sedation score of the research group was significantly higher than the control group, the difference was statistically significant (x2=6.13, P=0.002).The dosage of the fentanyl, propofol of the study group during the general anesthesia was significantly lower than that of the control group, the difference was statistically significant (t=5.54,P=0.02); and the difference of the two group in heart rate and blood pressure were statistical significance (t=4.97, P=0.03). But there is no significant difference in tracheal intubation time, the time spent before and after extubation, operation time and postoperative recovery time(P > 0.05). The two groups were not have muscle tremors, restless and other related adverse reactions. Conclusion Dexmedetomidine used in general anesthesia,has good effect, high safety coefficient, and has obvious sedative effect so it is worthy of clinical application.