CAJ | 학술논문

目的：探讨动脉粥样硬化型脑梗死患者同型半胱氨酸（Hcy ）水平及其与预后的关系。方法采用前瞻性队列研究方法连续登记2010-01-2013-05入住我科脑梗死患者，并进行TOAST分型，其中Ⅰ型入选为研究组，对照组为同期健康体检者，均行Hcy水平检测，对脑梗死患者入院时及3个月后采用美国国立卫生院神经功能缺损评分量表（NIHSS）及改良Rankin量表评分（MRS）进行评价，并对数据进行分析。结果研究组 Hcy水平较对照组明显升高，差异有统计学意义（P＜0·05）；研究组 Hcy水平与入院时NIHSS、MRS评分无相关性（P＞0·05），但与3个月后NIHSS和MRS改善程度相关（P＜0·05），＞15·57μmol/L患者预后差。结论血浆 Hcy水平增高可能是脑梗死的危险因素，可反映预后转归情况。
목적：탐토동맥죽양경화형뇌경사환자동형반광안산（Hcy ）수평급기여예후적관계。방법채용전첨성대렬연구방법련속등기2010-01-2013-05입주아과뇌경사환자，병진행TOAST분형，기중Ⅰ형입선위연구조，대조조위동기건강체검자，균행Hcy수평검측，대뇌경사환자입원시급3개월후채용미국국립위생원신경공능결손평분량표（NIHSS）급개량Rankin량표평분（MRS）진행평개，병대수거진행분석。결과연구조 Hcy수평교대조조명현승고，차이유통계학의의（P＜0·05）；연구조 Hcy수평여입원시NIHSS、MRS평분무상관성（P＞0·05），단여3개월후NIHSS화MRS개선정도상관（P＜0·05），＞15·57μmol/L환자예후차。결론혈장 Hcy수평증고가능시뇌경사적위험인소，가반영예후전귀정황。
Objective To investigate the level of homocysteine (Hcy) and the relationship between homocysteine and prog-nosis in atherosclerotic patients with cerebral infarction· Methods Cerebral infarction patients in our hospital from January 2010 to May 2013 were classified according to TOAST ,and then the TOAST-Ⅰpatients were considered as the research group and the healthy people at the same time were considered as the control group· The Hcy levels of two groups on admission and 3 months after treatment were evaluated by the NIHSS and MRS scores·Results The Hcy level of research group was higher than that of control group;the Hcy level of research group was related with or without the NIHSS and MRS scores (on admis-sion or 3 months after treatment)· The Hcy >15·57 μmol/l group had a worse prognosis· Conclusion Increased Hcy level may be the risk factors for patients with cerebral infarction ,which can reflect the patient’s prognosis.