CAJ | 학술논문

目的：探讨急性脑梗死患者血脂、血尿酸、纤维蛋白原和C反应蛋白的变化及意义。方法检测并进行比较120例急性脑梗死患者与110例健康体检者血脂、血糖、血尿酸；120例急性脑梗死患者依据血尿酸水平，分为正常血尿酸组与高血尿酸组，比较2组甘油三酯（TG）、总胆同醇（TcH）、高密度脂蛋白胆固醇（HDL-c）、低密度脂蛋白胆同醇（LDL-c）、血尿酸（μA）、纤维蛋白原（Fib）、血糖（GLU）、C反应蛋白（CRP）。结果脑梗死组μA、GLU水平较健康对照组升高，差异有统计学意义（t＝4·736，P＝0·000；t＝5·99，P＝0·000）；脑梗死组依据尿酸进行分组，高尿酸组纤维蛋白原（Fib）差异有统计学意义（t＝2·279，P＝0·025）；血甘油三酯（TG）、总胆固醇（TcH）、高密度脂蛋白胆固醇（HDL-c）、低密度脂蛋白胆同醇（LDL-c）、血糖（GLU）、C反应蛋白（CRP）差异无统计学意义（P＞0·05）。结论血尿酸是急性脑梗死重要危险因素之一，血尿酸水平与纤维蛋白原呈正相关，可能参与凝血功能改变。
목적：탐토급성뇌경사환자혈지、혈뇨산、섬유단백원화C반응단백적변화급의의。방법검측병진행비교120례급성뇌경사환자여110례건강체검자혈지、혈당、혈뇨산；120례급성뇌경사환자의거혈뇨산수평，분위정상혈뇨산조여고혈뇨산조，비교2조감유삼지（TG）、총담동순（TcH）、고밀도지단백담고순（HDL-c）、저밀도지단백담동순（LDL-c）、혈뇨산（μA）、섬유단백원（Fib）、혈당（GLU）、C반응단백（CRP）。결과뇌경사조μA、GLU수평교건강대조조승고，차이유통계학의의（t＝4·736，P＝0·000；t＝5·99，P＝0·000）；뇌경사조의거뇨산진행분조，고뇨산조섬유단백원（Fib）차이유통계학의의（t＝2·279，P＝0·025）；혈감유삼지（TG）、총담고순（TcH）、고밀도지단백담고순（HDL-c）、저밀도지단백담동순（LDL-c）、혈당（GLU）、C반응단백（CRP）차이무통계학의의（P＞0·05）。결론혈뇨산시급성뇌경사중요위험인소지일，혈뇨산수평여섬유단백원정정상관，가능삼여응혈공능개변。
Objective To research on the significance and change of blood lipid ,blood uric acid ,fibrinogen and C-reactive protein in acute cerebral infarction patients·Methods The levels of CHO ,blood sugar and uric acid in 120 cases with acute cer-ebral infarction and 110 healthy persons were compared· On the basis of the level of serum uric acid ,120 patients with acute cerebral infarction divided into normal uric acid group and hyperuricemia group· The blood levels of alcohol triglycerides (TG) , total cholesterol (TCH) ,high-density lipoprotein cholesterol (HDL-C) ,low density lipoprotein cholesterol (LDL-C) ,blood u-ric acid (UA) ,fibrinogen (Fib) ,and glucose (GLU) ,C-reactive protein (CRP) were compared and analyzed·Results The levels of UA ,Fib ,GLU in acute cerebral infarction patients increased obviously compared with normal group (t=4·736 ,P=0·000 ;t=5·99 ,P=0·000)· According to the level of blood uric acid in the acute cerebral infarction group ,the Fib level in-creased significantly between hyperuricemia group and normal uric acid group(t=2·279 , P=0·025)· But the levels of TG , TCH ,HDL-C ,LDL-C ,GLU ,CRP had no statistical significant between the two groups(P>0·05)·Conclusion The level of blood uric acid is one of the important risk factors of acute cerebral infarction· There is a correlation between the level of uric acid and fibrinogen ,and it is more likely to participate in coagulation function.