CAJ | 학술논문

目的：研究不同剂量辛伐他汀对缺血性脑血管患者脑血管储备能力的影响。方法将90例缺血性脑血管患者分为常规组、强化组和对照组。对照组患者口服拜阿司匹林，对症治疗；常规组患者服用常规剂量辛伐他汀治疗；强化组服用强化剂量辛伐他汀治疗。检测比较患者治疗前后的脑血管储备能力。结果治疗6个月后，常规组屏气指数为1·21±0·13，脑血管储备能力为30·44±5·09；强化组屏气指数为1·54±0·11，脑血管储备能力为36·14±5·13；对照组的屏气指数为0·95±0·11，脑血管储备能力为21·42±5·20。3组患者的屏气指数和脑血管储备能力较治疗前均有一定程度增加，但强化组增加的幅度最明显。结论强化剂量的辛伐他汀对患者CVR有较好疗效。
목적：연구불동제량신벌타정대결혈성뇌혈관환자뇌혈관저비능력적영향。방법장90례결혈성뇌혈관환자분위상규조、강화조화대조조。대조조환자구복배아사필림，대증치료；상규조환자복용상규제량신벌타정치료；강화조복용강화제량신벌타정치료。검측비교환자치료전후적뇌혈관저비능력。결과치료6개월후，상규조병기지수위1·21±0·13，뇌혈관저비능력위30·44±5·09；강화조병기지수위1·54±0·11，뇌혈관저비능력위36·14±5·13；대조조적병기지수위0·95±0·11，뇌혈관저비능력위21·42±5·20。3조환자적병기지수화뇌혈관저비능력교치료전균유일정정도증가，단강화조증가적폭도최명현。결론강화제량적신벌타정대환자CVR유교호료효。
Objective To investigate the effects of different does simvastatin on the cerebrovascular reserve capacity (CVR) of patients with ischemic cerebrovascular disease·Methods 90 patients with ischemic cerebrovascular disease were di-vided into the control group (treated with oral bayaspirin) ,convention group (treated with conventional does simvastatin ) and strengthened group (treated with strengthened does simvastatin)· The cerebrovascular reserve capacities of three groups were compared·Results After being treated for 6 months ,the breath-holding index and CVR were 1·21 ± 0·13 and 30·44 ± 5·09 in the convention group ,1·54 ± 0·11 and 36·14 ± 5·13 in the strengthened group ,0·95 ± 0·11 and 21·42 ± 5·20 in the control group ,respectively· Compared with pretreatment ,the breath-holding index and CVR of three groups had certain degree of in-crease ,especially in the strengthened group·Conclusion Strengthened does simvastatin has better effect on the CVR of pa-tients w ith ischemic cerebrovascular disease.