CAJ | 학술논문

本文旨在使介入放射学科医师，特别是从事经皮冠状动脉介入治疗的心内科医师，对多种新一代药物洗脱支架（drug-eluting stents，DESs）及其抗血栓形成的作用或降低支架内血栓形成（stent thrombosis，ST）发病率的功效有更多的认知。为此，通过近期文献复习和研发产业/市场调研后，对第1代DESs并发ST的主要相关因素作了扼要的回顾性分析。继而，对近年来从技术革新和材料的更新/改进着手，成功研发出具有抗血栓形成作用的多种新一代DESs，包括支架平台材料和构型、载入药物、载体和载药技术的更新或改进等，依序以图文相结合的方式进行了综合性阐述。此外，对生物全降解性DESs的研发和前景也作了简要的探讨。
본문지재사개입방사학과의사，특별시종사경피관상동맥개입치료적심내과의사，대다충신일대약물세탈지가（drug-eluting stents，DESs）급기항혈전형성적작용혹강저지가내혈전형성（stent thrombosis，ST）발병솔적공효유경다적인지。위차，통과근기문헌복습화연발산업/시장조연후，대제1대DESs병발ST적주요상관인소작료액요적회고성분석。계이，대근년래종기술혁신화재료적경신/개진착수，성공연발출구유항혈전형성작용적다충신일대DESs，포괄지가평태재료화구형、재입약물、재체화재약기술적경신혹개진등，의서이도문상결합적방식진행료종합성천술。차외，대생물전강해성DESs적연발화전경야작료간요적탐토。
This paper aims to make a comprehensive review about the new generation drug-eluting stents and their effects of anti-thrombosis to decrease stent thrombosis (ST), which are very helpful for interventional radiologists, especially for cardiologists who are engaged in percutaneous coronary interventional therapy. Based on the review of recently published academic papers and the investigation of the manufacturers and market of stent, the main factors related to ST complication which is associated with new generation drug-eluting stents are retrospectively and briefly analyzed. Besides, a variety of new generation drug-eluting stents with anti-thrombosis effect that are being successfully developed recently with new technology and new materials, including the renewal or improvement of the stent platform, loaded drug, carrier and its loading technology, etc. are comprehensively described in this paper in a combination way of vivid pictures with corresponding essay. In addition, the development and the prospect in clinical application of biodegradable drug-eluting stents are also briefly discussed in this paper.