CAJ | 학술논문

目的：探讨经动脉化疗栓塞（TACE）联合索拉非尼治疗肝癌后短期内的肝动脉 DSA 血流动力学表现。方法回顾性分析30例 TACE 治疗肝癌病例，其中治疗组13例，对照组17例。治疗组除接受 TACE 治疗外，还在治疗前1周、或治疗后2周内开始口服索拉非尼400 mg 每日2次。对照组只给予TACE 治疗。分析患者第1次和3个月后 TACE 治疗的 DSA 图像。用 Photoshop 软件在动态系列 DSA 图像上测量肿瘤的染色灰度，并绘制肿瘤染色的时间-密度曲线。比较两组患者肿瘤染色的峰值强度（PV），达峰值时间（TP）和曲线上升支斜率（SU）。结果 Photoshop 软件可以测量 DSA 图像中肿瘤组织的染色灰度。治疗组治疗后的染色 PV 小于治疗前（分别为38．0±14．6和46．7±18．4，P =0．040）、也小于对照组治疗后的染色 PV（分别为38．0±14．6和54．4±19．8，P =0．011）。两组之间以及每组治疗前后的 TP 和 SU差异无统计学意义。结论 TACE 联合索拉非尼治疗肝癌后短期内的肝动脉 DSA 肿瘤染色峰值下降。
목적：탐토경동맥화료전새（TACE）연합색랍비니치료간암후단기내적간동맥 DSA 혈류동역학표현。방법회고성분석30례 TACE 치료간암병례，기중치료조13례，대조조17례。치료조제접수 TACE 치료외，환재치료전1주、혹치료후2주내개시구복색랍비니400 mg 매일2차。대조조지급여TACE 치료。분석환자제1차화3개월후 TACE 치료적 DSA 도상。용 Photoshop 연건재동태계렬 DSA 도상상측량종류적염색회도，병회제종류염색적시간-밀도곡선。비교량조환자종류염색적봉치강도（PV），체봉치시간（TP）화곡선상승지사솔（SU）。결과 Photoshop 연건가이측량 DSA 도상중종류조직적염색회도。치료조치료후적염색 PV 소우치료전（분별위38．0±14．6화46．7±18．4，P =0．040）、야소우대조조치료후적염색 PV（분별위38．0±14．6화54．4±19．8，P =0．011）。량조지간이급매조치료전후적 TP 화 SU차이무통계학의의。결론 TACE 연합색랍비니치료간암후단기내적간동맥 DSA 종류염색봉치하강。
Objective To investigate DSA- estimated hepatic arterial hemodynamics of hepatocellular carcinoma (HCC) determined shortly after transcatheter arterial chemoembolization (TACE) plus sorafenib treatment. Methods The clinical data of thirty HCC patients treated with TACE were retrospectively analyzed. The patients were divided into study group (n = 13) and control group (n = 17). Patients in the study group received additional oral administration of 400mg sorafenib twice a day one week before or two weeks after TACE procedure, while patients in the control group received TACE only. The initial DSA images as well as the images obtained at three months after TACE were analyzed. With the help of Photoshop software, the grey gradient of the tumor staining was measured on the series dynamic DSA images, based on which the time- density curve of the tumor was drawn. The peak density value (PV), the time to reach the peak (TP) and the slope of the upslope (SU) were determined, and the results were compared between the two groups. Results Photoshop software was used to measure the grey density values of the tumor staining on DSA images. In the study group, the post- treatment PV was smaller than the pre- treatment one, which were (38.0 ± 14.6) and (46.7 ± 18.4) respectively, the difference between the two groups was statistically significant (P = 0.040). The post- treatment PV of the study group was also smaller than that of the post -treatment PV of the control group (54.4 ± 19.8), and the difference between the two was also statistically significant (P = 0.011). No significant differences in TP values and SU values existed between the two groups as well as between the pre - treatment and post - treatment ones in each group. Conclusion After TACE.