CAJ | 학술논문

目的：探讨TACE术在既往曾有肝功能衰竭的肝癌患者中应用的安全性和有效性。方法既往有肝功能衰竭病史，接受TACE术的患者7例，既往肝功能衰竭痊愈距行TACE治疗时间平均3.5年。监测其术后不良反应，生化指标变化程度，至少随访6个月，与同期接受TACE术，且无肝功能衰竭病史的51例进行对比。结果有肝功能衰竭史的患者，TACE术后随访期内无相关性死亡，未发生严重不良反应，轻度不良反应发生率与对照组无显著差异，术后短期内，与对照组相比，丙氨酸转氨酶、总胆红素、凝血酶原时间、白蛋白均有明显异常，但术后1个月，上述指标均能恢复，且术后6个月随访，两组肿瘤控制率无明显差异。结论对于既往有肝功能衰竭病史，且有无法手术切除的肝癌患者，仍可行TACE术，且是一项安全的治疗手段。
목적：탐토TACE술재기왕증유간공능쇠갈적간암환자중응용적안전성화유효성。방법기왕유간공능쇠갈병사，접수TACE술적환자7례，기왕간공능쇠갈전유거행TACE치료시간평균3.5년。감측기술후불량반응，생화지표변화정도，지소수방6개월，여동기접수TACE술，차무간공능쇠갈병사적51례진행대비。결과유간공능쇠갈사적환자，TACE술후수방기내무상관성사망，미발생엄중불량반응，경도불량반응발생솔여대조조무현저차이，술후단기내，여대조조상비，병안산전안매、총담홍소、응혈매원시간、백단백균유명현이상，단술후1개월，상술지표균능회복，차술후6개월수방，량조종류공제솔무명현차이。결론대우기왕유간공능쇠갈병사，차유무법수술절제적간암환자，잉가행TACE술，차시일항안전적치료수단。
Objective To discuss the safety and efficacy of transcatheter arterial chemoembolization (TACE) in treating patients with inoperable hepatocellular carcinoma (HCC) who has a history of hepatic failure. Methods A total of 7 HCC patients who had a history of hepatic failure (study group) were enrolled in this study. TACE was carried out in all these 7 patients. Other 51 patients who had no liver failure history were used as the control group. All the patients were followed up for at least six months. The postoperative adverse events, changes of liver function and the prognosis were recorded, and the results were compared between the two groups. Results In the study group, neither treatment-related death nor severe adverse events occurred. No significant difference in the occurrence of mild adverse events existed between the two groups. After TACE the liver functions, including alanine aminotransferase, total bilirubin, prolonged prothrombin time, albumin, etc. in the study group were significantly worse than those in the control group,groups. Conclusion For patients with inoperable hepatocellular carcinoma who has a history of hepatic failure, TACE is a safe and effective treatment.