CAJ | 학술논문

目的：探索利用负载131I的骨水泥行经皮椎体成形术（PVP）治疗兔椎体肿瘤的安全性及有效性。方法将12只采用经皮穿刺接种法建立的兔VX2椎体肿瘤模型随机分成实验组和对照组，每组6只。实验组注射负载有放射性核素131I的骨水泥行PVP，对照组单纯注射骨水泥行PVP。两组实验动物于术前1 d、术后第4天检测血细胞计数，于PVP术前1 d及术后第1、4、8天行PET-CT检查，测定椎体肿瘤的核素标准化摄取值（SUV）。 PVP后第1、4、8天对实验组动物行SPECT检查，了解131I在体内分布情况，在治疗后第8天取肿瘤椎体标本行病理检查。结果所有实验动物都顺利接受PVP治疗，实验组的放射性核素平均使用放射剂量为（0.82±0.14）mCi/kg。两组实验动物PVP前、后血细胞计数结果差异无统计学意义。PVP后SPECT检查见131I主要聚集在病变椎体内，术后各时间点内其分布无明显变化。两组动物术前SUV值差异无统计学意义（F=0.765，P＞0.05），实验组动物PVP后椎体肿瘤的SUV值较术前明显降低，且数值稳定（F=423.792，P＜0.05）。病理检查结果显示实验组骨水泥周边肿瘤细胞坏死范围明显大于对照组。结论采用负载131I的骨水泥行PVP治疗椎体肿瘤，方法可行，短期内随访结果安全、有效。
목적：탐색이용부재131I적골수니행경피추체성형술（PVP）치료토추체종류적안전성급유효성。방법장12지채용경피천자접충법건립적토VX2추체종류모형수궤분성실험조화대조조，매조6지。실험조주사부재유방사성핵소131I적골수니행PVP，대조조단순주사골수니행PVP。량조실험동물우술전1 d、술후제4천검측혈세포계수，우PVP술전1 d급술후제1、4、8천행PET-CT검사，측정추체종류적핵소표준화섭취치（SUV）。 PVP후제1、4、8천대실험조동물행SPECT검사，료해131I재체내분포정황，재치료후제8천취종류추체표본행병리검사。결과소유실험동물도순리접수PVP치료，실험조적방사성핵소평균사용방사제량위（0.82±0.14）mCi/kg。량조실험동물PVP전、후혈세포계수결과차이무통계학의의。PVP후SPECT검사견131I주요취집재병변추체내，술후각시간점내기분포무명현변화。량조동물술전SUV치차이무통계학의의（F=0.765，P＞0.05），실험조동물PVP후추체종류적SUV치교술전명현강저，차수치은정（F=423.792，P＜0.05）。병리검사결과현시실험조골수니주변종류세포배사범위명현대우대조조。결론채용부재131I적골수니행PVP치료추체종류，방법가행，단기내수방결과안전、유효。
Objective To preliminarily evaluate the safety and efficacy of percutaneous vertebroplasty (PVP) with 131I-loaded bone cement in treating vertebral tumor in rabbit models. Methods Twelve New Zealand white rabbits with lumbar vertebral tumor, which was established by puncturing transplant of VX2 carcinoma, were randomly and equally divided into the study group and the control group with 6 rabbits in each group. PVP with injection of 131I-loaded bone cement was carried out in the rabbits of the study group, while PVP with injection of pure bone cement was employed in the rabbits of the control group. The blood cell count was determined in all the animals one day before PVP as well as on the 4th day after PVP. PET-CT examination was performed one day before PVP as well as on the 4th day after PVP to check the stand uptake value (SUV) of each vertebral tumor. SPECT was performed in all rabbits of the study group at one, 4 and 8 days after PVP respectively to estimate the distribution of 131I in the animals’ bodies. Eight days after PVP, blood cell counts, which were determined both before and after PVP, existed between the study group and the control group. SPECT that was performed after PVP indicated that 131I was mainly accumulated within PVP-treated vertebrae, and the distribution of 131I showed no obvious changes at different points of time after the procedure. Before PVP, the difference in SUV between the two groups was of no statistical significance (F = 0.765, P > 0.05). In the study group, the postoperative SUV was significantly lower than the preoperative SUV (F = 423.792, P < 0.05). Pathological examination showed that the extent of tumor cell necrosis around the bone cement in the study group was remarkably bigger than that in the control group. Conclusion In treating vertebral tumors with PVP, the use of 131I-loaded bone cement is clinically feasible, and short-term follow-up indicates that this technique is safe and effective.