CAJ | 학술논문

目的：探讨经肝动脉化疗栓塞术（TACE）联合经皮肝穿刺注射热碘油治疗大肝癌的临床疗效。方法86例原发性肝癌随机分为2组，43例患者采用TACE术后并经皮肝穿刺注射热碘油治疗作为治疗组；另外43例患者TACE治疗作为对照组。结果治疗组有效率为68%，对照组有效率为53%，两组间差异有统计学意义（P<0.05）。两组术后肿瘤大小变化差异有统计学意义（P<0.05）；术后随访6、12、18、24个月生存例数和生存率分别为：43例（100%），36例（84%），23例（53%），14例（33%）；对照组分别为：40例（94%），30例（70%），16例（37%）和9例（21%）。但两组术后肝功能损害比较差异无统计学意义。结论经皮肝穿刺注射热碘油联合TACE治疗原发性肝癌的效果明显优于常规TACE治疗。
목적：탐토경간동맥화료전새술（TACE）연합경피간천자주사열전유치료대간암적림상료효。방법86례원발성간암수궤분위2조，43례환자채용TACE술후병경피간천자주사열전유치료작위치료조；령외43례환자TACE치료작위대조조。결과치료조유효솔위68%，대조조유효솔위53%，량조간차이유통계학의의（P<0.05）。량조술후종류대소변화차이유통계학의의（P<0.05）；술후수방6、12、18、24개월생존례수화생존솔분별위：43례（100%），36례（84%），23례（53%），14례（33%）；대조조분별위：40례（94%），30례（70%），16례（37%）화9례（21%）。단량조술후간공능손해비교차이무통계학의의。결론경피간천자주사열전유연합TACE치료원발성간암적효과명현우우상규TACE치료。
Objective To investigate the clinic effects of transcatheter arterial chemoembolization (TACE) combined with injection of hyper- thermic lipiodol into tumor body in treating large hepatic carcinoma. Methods A total of 86 patients with primary hepatic carcinoma were randomly and equally divided into the study group (n = 43) and control group (n = 43). TACE combined with injection of hyper-thermic lipiodol into tumor body was carried out in the patients of the study group , while only TACE was performed in the patients of the control group. The results were compared between the two groups. Results The effective rate of the study group and the control group was 68%and 53%respectively , and the difference between the two groups was statistically significant. The difference in the changes of tumor size after the treatment between the two groups was also statistically significant. In the study group, the survival rates at 6, 12, 18 and 24 months after the treatment were 100% (n = 43), 84% (n = 36), 53% (n = 23) and 33%(n=14) respectively, while in the control group the survival rates were 94% (n=40), 70% (n=30), 37%(n = 16) and 21%(n = 9) respectively. No statistically significant differences in postoperative liver function damage existed between the two groups. Conclusion TACE combined with injection of hyper-thermic lipiodol into tumor body is obviously superior to routine TACE in treating large hepatic carcinoma.