国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2014年
4期
315-317
,共3页
急性左心力衰竭%参脉注射液%临床研究
急性左心力衰竭%參脈註射液%臨床研究
급성좌심력쇠갈%삼맥주사액%림상연구
Acute left heart failure%Shenmai injection%Clinical research
目的：观察参脉注射液辅助西医常规疗法治疗急性左心力衰竭的临床疗效。方法采用随机数字表法按1∶1的比例将132例患者随机分为两组各66例，对照组采用西地兰、卡托普利、利尿剂及氨茶碱等治疗。治疗组在对照组治疗基础上静滴参脉注射液，1次/d，两组均治疗1个月后观察患者左室射血分数（LVEF）、左窒舒张末内径（LVEDD）值、B型利钠肽（BNP）指标变化，及两组患者的24 h动态心电图。结果两组患者LVEF值与BNP浓度治疗后[治疗组分别为(40.42±4.32)%、(306.57±201.21)pg/ml，对照组分别为(37.92±3.32)%、(451.51±294.23)pg/ml]均较同组治疗前明显改善[治疗组分别为(35.28±4.15)%、(540.17±382.23)pg/ml，对照组分别为(35.13±2.35)%、(572.35±422.21)pg/ml]，且治疗组疗效优于对照组（P＜0.05）。两组LVEDD、24 h平均心率治疗后[治疗组分别为(59.81±8.38)mm、(79.62±6.38)次/min，对照组分别为(60.91±7.31)mm、(82.61±6.32)次/min]均较同组治疗前[治疗组分别为(60.87±7.75)mm、(85.03±7.75)次/min，对照组分别为(61.81±7.35)mm、(86.23±8.35)次/min]有所改善，但差异无统计学意义（P＞0.05）。结论参脉注射液对急性左心力衰竭有良好的治疗作用。
目的：觀察參脈註射液輔助西醫常規療法治療急性左心力衰竭的臨床療效。方法採用隨機數字錶法按1∶1的比例將132例患者隨機分為兩組各66例，對照組採用西地蘭、卡託普利、利尿劑及氨茶堿等治療。治療組在對照組治療基礎上靜滴參脈註射液，1次/d，兩組均治療1箇月後觀察患者左室射血分數（LVEF）、左窒舒張末內徑（LVEDD）值、B型利鈉肽（BNP）指標變化，及兩組患者的24 h動態心電圖。結果兩組患者LVEF值與BNP濃度治療後[治療組分彆為(40.42±4.32)%、(306.57±201.21)pg/ml，對照組分彆為(37.92±3.32)%、(451.51±294.23)pg/ml]均較同組治療前明顯改善[治療組分彆為(35.28±4.15)%、(540.17±382.23)pg/ml，對照組分彆為(35.13±2.35)%、(572.35±422.21)pg/ml]，且治療組療效優于對照組（P＜0.05）。兩組LVEDD、24 h平均心率治療後[治療組分彆為(59.81±8.38)mm、(79.62±6.38)次/min，對照組分彆為(60.91±7.31)mm、(82.61±6.32)次/min]均較同組治療前[治療組分彆為(60.87±7.75)mm、(85.03±7.75)次/min，對照組分彆為(61.81±7.35)mm、(86.23±8.35)次/min]有所改善，但差異無統計學意義（P＞0.05）。結論參脈註射液對急性左心力衰竭有良好的治療作用。
목적：관찰삼맥주사액보조서의상규요법치료급성좌심력쇠갈적림상료효。방법채용수궤수자표법안1∶1적비례장132례환자수궤분위량조각66례，대조조채용서지란、잡탁보리、이뇨제급안다감등치료。치료조재대조조치료기출상정적삼맥주사액，1차/d，량조균치료1개월후관찰환자좌실사혈분수（LVEF）、좌질서장말내경（LVEDD）치、B형리납태（BNP）지표변화，급량조환자적24 h동태심전도。결과량조환자LVEF치여BNP농도치료후[치료조분별위(40.42±4.32)%、(306.57±201.21)pg/ml，대조조분별위(37.92±3.32)%、(451.51±294.23)pg/ml]균교동조치료전명현개선[치료조분별위(35.28±4.15)%、(540.17±382.23)pg/ml，대조조분별위(35.13±2.35)%、(572.35±422.21)pg/ml]，차치료조료효우우대조조（P＜0.05）。량조LVEDD、24 h평균심솔치료후[치료조분별위(59.81±8.38)mm、(79.62±6.38)차/min，대조조분별위(60.91±7.31)mm、(82.61±6.32)차/min]균교동조치료전[치료조분별위(60.87±7.75)mm、(85.03±7.75)차/min，대조조분별위(61.81±7.35)mm、(86.23±8.35)차/min]유소개선，단차이무통계학의의（P＞0.05）。결론삼맥주사액대급성좌심력쇠갈유량호적치료작용。
Objective To observe the effect of treating acute left heart failure with Shenmai injection and auxiliary conventional western medicine. Methods 132 patients were randomly divided into a control group and a treatment group, with 66 cases in each group. The control group was treated with lanatoside C, captopril, diuretics, and aminophylline. While the treatment group was additionally treated with Shenmai injection on the basis of the control group. Left ventricular ejection fraction(LVEF), left smothering end-diastolic diameter(LVEDD)value, the index of b-type natriuretic peptide(BNP), and 24 h dynamic electrocardiogram(ecg)were observed in both groups after 1 month’s treatment. Results LVEF and BNP were improved in both groups after the treatment[LVEF and BNP were(40.42 ± 4.32)%, (306.57 ± 201.21)pg/ml in the treatment group and(37.92±3.32)%, (451.51±294.23)pg/ml in the control group before the treatment;(35.28±4.15)%, (540.17±382.23)pg/ml in the treatment group and(35.13±2.35)%, (572.35± 422.21)pg/ml in the control group after the treatment], and the curative effect in the treatment group was better than the control group(P<0.05). LVEDD and 24 h average heart rate were also improved in both groups after the treatment [LVEDD and 24 h average heart rate were(59.81±59.81)mm, (79.62±6.38)times/min in the treatment group and(60.91±7.31)mm, (82.61±6.32)times/min in the control group before the treatment;(60.87 ± 7.75)mm, (85.03 ± 7.75)times/min in the treatment group and(61.81 ± 7.35)mm,(86.23 ± 8.35)times/min in the control group after the treatment], but there was no statistical differenc(P>0.05). Conclusion Shenmai injection has good effects in the treatment of acute left heart failure.
