介入放射学杂志
介入放射學雜誌
개입방사학잡지
JOURNAL OF INTERVENTIONAL RADIOLOGY
2014年
9期
772-776
,共5页
迟秀婷%沈加林%程杰军%王稽%许建荣
遲秀婷%瀋加林%程傑軍%王稽%許建榮
지수정%침가림%정걸군%왕계%허건영
CT灌注成像%5cm以下肝癌%TACE
CT灌註成像%5cm以下肝癌%TACE
CT관주성상%5cm이하간암%TACE
CT perfusion imaging%small hepatocellular carcinoma%transcatheter arterial chemoembolization
目的：探讨CT灌注成像在5 cm以下肝癌TACE （transcatheter arterial chemoembolization）治疗前后血流动力学变化方面的临床应用价值。方法12例5 cm以下肝癌患者于TACE术前1~2 d及术后3~4周行肝脏CT灌注成像，通过获取的灌注参数分析栓塞前后的肿瘤组织、栓塞前肿瘤组织与正常组织及栓塞后肿瘤活性组织与正常组织的血流变化情况。结果栓塞前肿瘤组织的血流量（BF），肝动脉分数（HAF），肝动脉灌注量（HAP），表面通透性（PS）较正常组织显著增加（P﹤0.01），而栓塞后肿瘤组织血流各组灌注参数（血容量，BV除外）较栓塞前显著降低（P﹤0.01），栓塞后的肿瘤活性组织较正常组织BF， PS，HAF，HAP增加（P﹤0.05）。结论 CT灌注成像在5 cm以下肝癌的诊断、TACE治疗后的血流动力学变化评估及术后残余活性病灶的显示方面具有较高的临床应用价值。
目的：探討CT灌註成像在5 cm以下肝癌TACE （transcatheter arterial chemoembolization）治療前後血流動力學變化方麵的臨床應用價值。方法12例5 cm以下肝癌患者于TACE術前1~2 d及術後3~4週行肝髒CT灌註成像，通過穫取的灌註參數分析栓塞前後的腫瘤組織、栓塞前腫瘤組織與正常組織及栓塞後腫瘤活性組織與正常組織的血流變化情況。結果栓塞前腫瘤組織的血流量（BF），肝動脈分數（HAF），肝動脈灌註量（HAP），錶麵通透性（PS）較正常組織顯著增加（P﹤0.01），而栓塞後腫瘤組織血流各組灌註參數（血容量，BV除外）較栓塞前顯著降低（P﹤0.01），栓塞後的腫瘤活性組織較正常組織BF， PS，HAF，HAP增加（P﹤0.05）。結論 CT灌註成像在5 cm以下肝癌的診斷、TACE治療後的血流動力學變化評估及術後殘餘活性病竈的顯示方麵具有較高的臨床應用價值。
목적：탐토CT관주성상재5 cm이하간암TACE （transcatheter arterial chemoembolization）치료전후혈류동역학변화방면적림상응용개치。방법12례5 cm이하간암환자우TACE술전1~2 d급술후3~4주행간장CT관주성상，통과획취적관주삼수분석전새전후적종류조직、전새전종류조직여정상조직급전새후종류활성조직여정상조직적혈류변화정황。결과전새전종류조직적혈류량（BF），간동맥분수（HAF），간동맥관주량（HAP），표면통투성（PS）교정상조직현저증가（P﹤0.01），이전새후종류조직혈류각조관주삼수（혈용량，BV제외）교전새전현저강저（P﹤0.01），전새후적종류활성조직교정상조직BF， PS，HAF，HAP증가（P﹤0.05）。결론 CT관주성상재5 cm이하간암적진단、TACE치료후적혈류동역학변화평고급술후잔여활성병조적현시방면구유교고적림상응용개치。
Objective To investigate the clinical application of CT perfusion imaging in assessing the hemodynamic changes in patients with small hepatocellular carcinoma (<5 cm) before and after transcatheter arterial chemoembolization (TACE). Methods Twelve patients with small hepatocellular carcinoma were enrolled in this study. CT perfusion imaging of the liver was performed 1 - 2 days before and 3 - 4 weeks after TACE. By using the perfusion parameters the hemodynamics of the preoperative and postoperative tumor tissue, the hemodynamics of the preoperative tumor tissue and the normal tissue, and the hemodynamics of the postoperative active tumor tissue and the normal tissue were determined , and the results were compared between each other. Results Before TACE, the blood flow (BF), hepatic arterial fraction (HAF), hepatic arterial perfusion (HAP) and permeability of surface (PS) in the tumor tissue were significantly higher than those in the normal tissue (P < 0.01), while after TACE all the perfusion parameters except blood volume (BV) were significantly decreased in the tumor tissue (P < 0.01). After TACE, BF, PS, HAF and HAP in the activity tumor tissue were increased more than those in the normal tissue (P < 0.05). Conclusion CT perfusion imaging is of great clinical value in diagnosing < 5 cm hepatocellular carcinoma , in evaluating the hemodynamic changes after TACE and in demonstrating the activity of the residual tumor tissue.
