CAJ | 학술논문

目的：探讨肝动脉化疗栓塞术（TACE）联合索拉非尼治疗中晚期肝细胞肝癌（HCC）的护理方法。方法选取符合纳入标准的23例中晚期HCC患者，TACE术后3～5 d口服甲磺酸索拉非尼。期间观察、记录不良反应和并发症发生情况，出院患者由延续护理小组成员跟踪随访，予以健康教育和相应的护理干预措施。结果所有患者TACE术后均口服索拉非尼进行治疗，联合治疗的不良反应主要是：胃肠道反应（22例）和一过性肝功能损害（23例）。出院患者均得到定期随访和延续护理。结论 TACE联合索拉非尼治疗晚期肝细胞肝癌不良反应发生率较高，采用院内观察结合院外延续护理的方式护理此类患者，可减轻治疗期间并发症反应，提高患者的生存质量。
목적：탐토간동맥화료전새술（TACE）연합색랍비니치료중만기간세포간암（HCC）적호리방법。방법선취부합납입표준적23례중만기HCC환자，TACE술후3～5 d구복갑광산색랍비니。기간관찰、기록불량반응화병발증발생정황，출원환자유연속호리소조성원근종수방，여이건강교육화상응적호리간예조시。결과소유환자TACE술후균구복색랍비니진행치료，연합치료적불량반응주요시：위장도반응（22례）화일과성간공능손해（23례）。출원환자균득도정기수방화연속호리。결론 TACE연합색랍비니치료만기간세포간암불량반응발생솔교고，채용원내관찰결합원외연속호리적방식호리차류환자，가감경치료기간병발증반응，제고환자적생존질량。
Objective To discuss the nursing care for patients with advanced hepatocellular carcinoma (HCC) who are receiving transcatheter arterial chemoembolization (TACE) combined with sorafenib. Methods A total of 23 consecutive patients with advanced HCC who met the inclusion criteria were enrolled in this study. TACE was carried out in all patients. Three-five days after TACE the patients started to orally take sorafenib. During the treatment course, the patients were kept under close observation for adverse reactions and complications. After leaving the hospital the patients were followed up by the extended care team members, and health education as well as appropriate nursing intervention was carried out. Results All patients with advanced HCC took sorafenib orally after TACE. The major adverse events and complications were gastrointestinal adverse reactions (n = 22) and transient liver dysfunction (n = 23). After leaving the hospital all the patients received regular follow- up examination and extended nursing care. Conclusion Usually, the incidence of adverse reactions is higher in patients with advanced HCC after TACE combined with sorafenib treatment. Careful in-hospital observation and extended out-hospital nursing can reduce the incidence of adverse reactions and thus improve the patient’s quality of life.