国际中医中药杂志
國際中醫中藥雜誌
국제중의중약잡지
INTERNATIONAL JOURNAL OF TRIDITIONAL CHINESE MEDICINE
2014年
9期
819-820,823
,共3页
杨改琴%张炳岐%贾成文%左甲%贾松松
楊改琴%張炳岐%賈成文%左甲%賈鬆鬆
양개금%장병기%가성문%좌갑%가송송
针刺%背俞穴%慢性萎缩性胃炎%胃泌素%胃动素
針刺%揹俞穴%慢性萎縮性胃炎%胃泌素%胃動素
침자%배유혈%만성위축성위염%위비소%위동소
Acupuncturing%Back-Shu points%Chrounic atrophic gastritis%Gastrin%Motilin
目的：研究针刺背俞穴对慢性萎缩性胃炎（chrounic atrophic gastritis，CAG）模型大鼠胃泌素（GAS）、胃动素（MOT）的影响。方法采用随机数字表法将60只SD大鼠随机分为空白对照组、模型对照组、奥美拉唑组、针刺背俞穴组各15只，并以单双日间隔喂食饥饱失常法建立慢性萎缩性胃炎模型。空白对照组、模型对照组均灌服生理盐水，2 ml/次，1次/d；奥美拉唑组给予奥美拉唑0.44 mg/kg、克拉霉素6.92 mg/kg、甲硝唑7.6 mg/kg灌胃，1次/d；针刺背俞穴组针刺膈俞、肝俞、脾俞、胃俞、肾俞，留针15 min，1次/d。30 d后，用ELSIA法检测GAS、MOT含量。结果①模型对照组GAS含量（54.25±5.70）pg/ml明显低于空白对照组（66.63±5.99）pg/ml（P＜0.05）；与模型对照组比较，奥美拉唑组（62.70±8.55）pg/ml、针刺背俞穴组（66.27±3.79）pg/ml均较高（P＜0.05）。②模型对照组MOT含量（223.60±17.83）pg/ml高于空白对照组（188.45±8.90）pg/ml（P＜0.05）。奥美拉唑组（200.16±4.38）pg/ml、针刺背俞穴组（190.11±10.04）pg/ml均低于模型对照组（P均＜0.05）。结论针刺背俞穴疗法可增加CAG模型大鼠GAS含量、降低MOT含量，对CAG有效。
目的：研究針刺揹俞穴對慢性萎縮性胃炎（chrounic atrophic gastritis，CAG）模型大鼠胃泌素（GAS）、胃動素（MOT）的影響。方法採用隨機數字錶法將60隻SD大鼠隨機分為空白對照組、模型對照組、奧美拉唑組、針刺揹俞穴組各15隻，併以單雙日間隔餵食饑飽失常法建立慢性萎縮性胃炎模型。空白對照組、模型對照組均灌服生理鹽水，2 ml/次，1次/d；奧美拉唑組給予奧美拉唑0.44 mg/kg、剋拉黴素6.92 mg/kg、甲硝唑7.6 mg/kg灌胃，1次/d；針刺揹俞穴組針刺膈俞、肝俞、脾俞、胃俞、腎俞，留針15 min，1次/d。30 d後，用ELSIA法檢測GAS、MOT含量。結果①模型對照組GAS含量（54.25±5.70）pg/ml明顯低于空白對照組（66.63±5.99）pg/ml（P＜0.05）；與模型對照組比較，奧美拉唑組（62.70±8.55）pg/ml、針刺揹俞穴組（66.27±3.79）pg/ml均較高（P＜0.05）。②模型對照組MOT含量（223.60±17.83）pg/ml高于空白對照組（188.45±8.90）pg/ml（P＜0.05）。奧美拉唑組（200.16±4.38）pg/ml、針刺揹俞穴組（190.11±10.04）pg/ml均低于模型對照組（P均＜0.05）。結論針刺揹俞穴療法可增加CAG模型大鼠GAS含量、降低MOT含量，對CAG有效。
목적：연구침자배유혈대만성위축성위염（chrounic atrophic gastritis，CAG）모형대서위비소（GAS）、위동소（MOT）적영향。방법채용수궤수자표법장60지SD대서수궤분위공백대조조、모형대조조、오미랍서조、침자배유혈조각15지，병이단쌍일간격위식기포실상법건립만성위축성위염모형。공백대조조、모형대조조균관복생리염수，2 ml/차，1차/d；오미랍서조급여오미랍서0.44 mg/kg、극랍매소6.92 mg/kg、갑초서7.6 mg/kg관위，1차/d；침자배유혈조침자격유、간유、비유、위유、신유，류침15 min，1차/d。30 d후，용ELSIA법검측GAS、MOT함량。결과①모형대조조GAS함량（54.25±5.70）pg/ml명현저우공백대조조（66.63±5.99）pg/ml（P＜0.05）；여모형대조조비교，오미랍서조（62.70±8.55）pg/ml、침자배유혈조（66.27±3.79）pg/ml균교고（P＜0.05）。②모형대조조MOT함량（223.60±17.83）pg/ml고우공백대조조（188.45±8.90）pg/ml（P＜0.05）。오미랍서조（200.16±4.38）pg/ml、침자배유혈조（190.11±10.04）pg/ml균저우모형대조조（P균＜0.05）。결론침자배유혈요법가증가CAG모형대서GAS함량、강저MOT함량，대CAG유효。
Objective To study the effect of gastrin, motilin of chronic atrophic gastritis model in rats by acupuncturing at back-shu points. Methods 60 SD rats were randomly divided into blank control group, model control group, omeprazole group, back-shu points group, with 15 rats in each group, and to establish the model of chronic atrophic gastritis by irregular diet that given rats odd and even days. The blank control group, model control group were fed with normal saline, 2ml/time, 1 time/day. The omeprazole group was given oral gavage(Omeprazole 0.44 mg/kg, Clarithromycin 6.92 mg/kg, Metronidazole 7.6 mg/kg), 1 time/day. Back-shu points group received acupuncture at “Geshu”“Ganshu”“Pishu”“Weishu”“Shenshu”, retaining 15 min, 1 time/day. After 30 days, the content of ELSIA was used to detect the serum gastrin, motilin. Results ①GAS of model control group(54.25±5.70)pg/ml was significantly decreased compared with blank control group(66.63± 5.99)pg/ml, the difference was statistically significant (P<0.05). Compared with the model control group, GAS content of omeprazole group(62.70±8.55)pg/ml and back-shu Points group(66.27±3.79)pg/ml were higher, showed significant differences(P<0.05). ②MOT of model control group(223.60±17.83)pg/ml was significantly increased compared with the blank control group(188.45 ± 8.90)pg/ml, the difference was statistically significant(P<0.05). MOT of omeprazole group(200.16 ± 4.38)pg/ml and back-shu Points group(190.11±10.04)pg/ml were lower than those in the model control group, there was statistically significant difference(P<0.05). Conclusion Acupuncturing at back-shu acupoints can increase the content of GAS, reduce content of MOT, regulate gastrointestinal hormone in rats of chronic atrophic gastritis model.
