CAJ | 학술논문

目的：评价痰热清注射液预防放射性肺炎的有效性。方法检索2000年1月至2013年7月中国期刊全文数据库、中国生物医学文献数据库、维普和万方等数据库、Pubmed、Google学术等，由2名研究者独立阅读、提取文献，进行质量评价。采用Revman 5.2软件进行meta分析。结果共纳入11篇文献，939例患者。通过meta分析，痰热清注射组与放疗组的放射性肺炎发生率比较，OR（95%CI）为0.42（0.30，0.57）差异有统计学意义（ P＜0.05）。3级以上放射性肺炎、放射性肺纤维化发生率比较， OR（95%CI）分别为0.19（0.11，0.35），0.35（0.23，0.53），P＝0.65。发生放射性肺炎的平均剂量、平均放射时间比较，OR（95%CI）为7.39（4.41，10.38），7.72（6.84，8.61）差异有统计学意义（P＜0.05）。结论痰热清注射液对预防放射性肺炎有一定作用，同时降低3级以上放射性肺炎、肺纤维化发生率，可延长放射时间，提高放射性肺炎的发生剂量。
목적：평개담열청주사액예방방사성폐염적유효성。방법검색2000년1월지2013년7월중국기간전문수거고、중국생물의학문헌수거고、유보화만방등수거고、Pubmed、Google학술등，유2명연구자독립열독、제취문헌，진행질량평개。채용Revman 5.2연건진행meta분석。결과공납입11편문헌，939례환자。통과meta분석，담열청주사조여방료조적방사성폐염발생솔비교，OR（95%CI）위0.42（0.30，0.57）차이유통계학의의（ P＜0.05）。3급이상방사성폐염、방사성폐섬유화발생솔비교， OR（95%CI）분별위0.19（0.11，0.35），0.35（0.23，0.53），P＝0.65。발생방사성폐염적평균제량、평균방사시간비교，OR（95%CI）위7.39（4.41，10.38），7.72（6.84，8.61）차이유통계학의의（P＜0.05）。결론담열청주사액대예방방사성폐염유일정작용，동시강저3급이상방사성폐염、폐섬유화발생솔，가연장방사시간，제고방사성폐염적발생제량。
Objective To evaluate the effectiveness of Tanreqing Injection for the preventive of radiation pneumonitis. Methods Retrieving literatures in CNKI, CBM,VIP and WanFang, Medline, Google Scholar database from January 2000 to July 2013.Two researchers extracted and evaluated the quality of all the data independently.RevMan 5.2 software was used for statistical analysis. Results 11 papers and 939 patients were involved in the study. Meta analysis showed statistical difference for the index of marked efficacy between Tanreqing group and radiation group with OR(95%CI)is 0.42(0.30, 0.57). Significant difference was found for the index of more than Grade 3 of radiation pneumonitis, radiation pulmonary fibrosis with OR(95% CI) 0.19(0.11, 0.35), 0.35(0.23, 0.53), respectively(P=0.65). Statistical difference was observed for the index of the dose of radiation and the average onset time of radiation pneumonitis with OR(95%CI) 7.39(4.41, 10.38) and 7.72(6.84, 8.61) respectively. Conclusion Meta analysis based on current limited clinical research results preliminary shows that. Tanreqing injection has a good clinical efficacy for the preventive effect of radiation pneumonitis. The use of Tanreqing injection could reduce the rate of more than Grade 3 of radiation pneumonitis as well as radiation pulmonary fibrosis, extend the onset time and increase the dose which leads to radiation pneumonitis.