CAJ | 학술논문

目的：评价苓芍枣仁颗粒联合酒石酸托特罗定片治疗女性膀胱过度活动症（overactive bladder，OAB）的有效性。方法收集2012年12月至2013年7月中国中医科学院西苑医院泌尿外科女性膀胱过度活动症门诊患者50例，按随机数字表法将患者分为两组各25例。对照组采用酒石酸托特罗定片治疗，治疗组在对照组治疗基础上配合苓芍枣仁颗粒治疗，两组均治疗4周后，通过膀胱过度活动症状量表（OBASS）和尿急量表的评分比较，评价两组患者的临床疗效。结果同组治疗前后OBASS评分[治疗组分别为（12.16±1.39）分、（3.24±0.61）分，对照组分别为（13.12±1.45）分、（8.81±1.55）分]比较，差异有统计学意义（P＜0.01）；尿急量表评分[治疗组分别为（3.99±0.78）分、（1.04±0.72）分，对照组分别为（4.01±0.71）分、（2.61±0.88）分]比较，差异有统计学意义（P＜0.01）。两组治疗后 OABSS 评分、尿急评分比较，差异均有统计学意义（P 均＜0.01）。结论苓芍枣仁颗粒联合酒石酸托特罗定片治疗膀胱过度活动症的效果优于单用酒石酸托特罗定片。
목적：평개령작조인과립연합주석산탁특라정편치료녀성방광과도활동증（overactive bladder，OAB）적유효성。방법수집2012년12월지2013년7월중국중의과학원서원의원비뇨외과녀성방광과도활동증문진환자50례，안수궤수자표법장환자분위량조각25례。대조조채용주석산탁특라정편치료，치료조재대조조치료기출상배합령작조인과립치료，량조균치료4주후，통과방광과도활동증상량표（OBASS）화뇨급량표적평분비교，평개량조환자적림상료효。결과동조치료전후OBASS평분[치료조분별위（12.16±1.39）분、（3.24±0.61）분，대조조분별위（13.12±1.45）분、（8.81±1.55）분]비교，차이유통계학의의（P＜0.01）；뇨급량표평분[치료조분별위（3.99±0.78）분、（1.04±0.72）분，대조조분별위（4.01±0.71）분、（2.61±0.88）분]비교，차이유통계학의의（P＜0.01）。량조치료후 OABSS 평분、뇨급평분비교，차이균유통계학의의（P 균＜0.01）。결론령작조인과립연합주석산탁특라정편치료방광과도활동증적효과우우단용주석산탁특라정편。
Objective To evaluate the efficacy ofLingshao-Zaoren particle combined with Tolterodine Tartrate tablet in the treatment of overactive bladder in women.Methods A total of fifty female patients diagnosed with overactive bladder were randomized to receivingLingshao-Zaoren particle combined with Tolterodine Tartrate tablet group(treatment group,n=25) or only Tolterodine Tartrate tablet group(control group, n=25). Both groups were treated for 4 weeks. Changes of scores from the Overactive Bladder Symptom Scale (OBASS) and the Urgent Urination Scale were assessed.Results The scores from the OBASS improved significantly after treatment than those before treatment in both groups(in the treatment group: 3.24±0.61vs.12.16± 1.39,P<0.01; in the control group: 8.81±1.55vs.13.12±1.45,P<0.01) and so did the Urgent Urination Scale (in the treatment group: 1.04±0.72vs. 3.99±0.78,P<0.01; in the control group: 2.61±0.88vs.4.01±0.71,P<0.01) . There were significantly greater improvements in the scores from the OBASS and the Urgent Urination Scale in the treatment group than those in the control group(allP<0.01).ConclusionLingshao-Zaoren particle combined with Tolterodine Tartrate tablet was superior to only Tolterodine Tartrate tablet for the treatment of overactive bladder in women.