CAJ | 학술논문

目的：观察益元固肠汤口服联合愈疡液灌肠对慢性溃疡性结肠炎的临床疗效。方法选择符合纳入标准的UC缓解期患者70例，随机分为两组：对照组34例，给予美沙拉嗪口服，1 g/次，2次/d；治疗组36例，给予益元固肠汤口服，1剂/d，并配合愈疡液每晚保留灌肠。两组均以8周为1个疗程，治疗1疗程后，比较两组临床主要症状、内窥镜、组织病理学、红细胞沉降率（ESR）、C反应蛋白（CRP）及白细胞介素-8（IL-8）、白细胞介素-13（IL-13）的改变情况。结果治疗组总有效率为94.44%（34/36）、对照组为64.71%（22/34），两组比较差异有统计学意义（Z＝-4.207，P＜0.05）。治疗组在临床症状、肠镜黏膜象、黏膜病理组织学疗效优于对照组（P＜0.05）。治疗组ESR、CRP、IL-8、IL-13治疗前分别为（13.5±3.3）mm/h、（8.26±1.54）mg/L、（0.85±0.17）ng/ml、（37.18±14.58）pg/ml，治疗后分别为（7.0±2.4）mm/h、（3.56±1.03）mg/L、（0.38±0.08）ng/ml、（76.33±23.74）pg/ml；对照组ESR、CRP、IL-8、IL-13治疗前分别为（14.5±4.8）mm/h、（8.41±1.36）mg/L、（0.86±0.15）ng/ml、（40.46±14.47）pg/ml，治疗后分别为（7.5±3.5）mm/h、（3.63±1.10）mg/L、（0.36±0.07）ng/ml、（55.84±17.52）pg/ml；两组ESR、CRP、IL-8均较治疗前下降，IL-13治疗后升高（P＜0.05）。治疗后，两组ESR、CRP、IL-8比较，差异无统计学意义（P均＞0.05）；治疗组IL-13高于对照组（P＜0.05）。结论益元固肠汤口服配合愈疡液灌肠治疗脾肾亏虚，瘀毒内蕴证疗效确切。
목적：관찰익원고장탕구복연합유양액관장대만성궤양성결장염적림상료효。방법선택부합납입표준적UC완해기환자70례，수궤분위량조：대조조34례，급여미사랍진구복，1 g/차，2차/d；치료조36례，급여익원고장탕구복，1제/d，병배합유양액매만보류관장。량조균이8주위1개료정，치료1료정후，비교량조림상주요증상、내규경、조직병이학、홍세포침강솔（ESR）、C반응단백（CRP）급백세포개소-8（IL-8）、백세포개소-13（IL-13）적개변정황。결과치료조총유효솔위94.44%（34/36）、대조조위64.71%（22/34），량조비교차이유통계학의의（Z＝-4.207，P＜0.05）。치료조재림상증상、장경점막상、점막병리조직학료효우우대조조（P＜0.05）。치료조ESR、CRP、IL-8、IL-13치료전분별위（13.5±3.3）mm/h、（8.26±1.54）mg/L、（0.85±0.17）ng/ml、（37.18±14.58）pg/ml，치료후분별위（7.0±2.4）mm/h、（3.56±1.03）mg/L、（0.38±0.08）ng/ml、（76.33±23.74）pg/ml；대조조ESR、CRP、IL-8、IL-13치료전분별위（14.5±4.8）mm/h、（8.41±1.36）mg/L、（0.86±0.15）ng/ml、（40.46±14.47）pg/ml，치료후분별위（7.5±3.5）mm/h、（3.63±1.10）mg/L、（0.36±0.07）ng/ml、（55.84±17.52）pg/ml；량조ESR、CRP、IL-8균교치료전하강，IL-13치료후승고（P＜0.05）。치료후，량조ESR、CRP、IL-8비교，차이무통계학의의（P균＞0.05）；치료조IL-13고우대조조（P＜0.05）。결론익원고장탕구복배합유양액관장치료비신우허，어독내온증료효학절。
Objective To research the efficacy of oralYiyuan-Guchangdecoction and enema retention ofYuyangye in treating chronic ulcerative colitis(CUC).Methods 70 patients of CUC were randomly divided into two groups: a control group of 34 patients, treated by mesalazine(etiasa) orally, 1g/twice daily; and a test group of 36 patients, treated byYuyangyedecoction for oral administration andYuyangyeenema retention. The treatment course of both groups was 8 weeks. The curative effect, clinical symptoms, endoscopic sign and pathology, and ESR, CRP, IL-8, and IL-13 after one course of treatment, were analyzed statistically.Results The total effect of the test group and the control group was 94.44%(34/36) and 64.71%(22/34), and the difference was significant statistically(Z=-4.207,P<0.05). The effects of test group were superior than the control group in terms of the clinical symptoms, endoscopic sign, and histopathology(P<0.05). The ESR, CRP, IL-8, IL-13 of the test group were(13.5±3.3)mm/h,(8.26±1.54)mg/L,(0.85±0.17)ng/ml,(37.18± 14.58)pg/ml before the treament, and(7.0±2.4)mm/h, (3.56±1.03)mg/L,(0.38±0.08)ng/ml, (76.33± 23.74)pg/ml after the treatment; The ESR、CRP、IL-8、IL-13 of control group were(14.5±4.8)mm/h, (8.41 ±1.36)mg/L,(0.86±0.15)ng/ml,(40.46±14.47)pg/ml before the treatment and(7.5±3.5)mm/h,(3.63± 1.10)mg/L,(0.36±0.07)ng/ml,(55.84±17.52)pg/ml after the treatment. ESR, CRP and IL-8 of both groups decreased significantly(P<0.05), while IL-13 significantly increased(P<0.05). ESR, CRP, IL-8 had no obvious statistical significance(P>0.05)between the two groups, while IL-13 of the test group was superior than the control group(P<0.05).Conclusion The therapeutic effect of oralYiyuan-Guchangdecoction and Yuyangyeenema retention is good in treating chronic ulcerative colitis.