中国性科学
中國性科學
중국성과학
THE CHINESE JOURNAL OF HUMAN SEXUALITY
2014年
9期
3-6
,共4页
潘美洲%张刚%方舟%梁明
潘美洲%張剛%方舟%樑明
반미주%장강%방주%량명
他达拉非%勃起功能障碍%随机对照试验%meta分析
他達拉非%勃起功能障礙%隨機對照試驗%meta分析
타체랍비%발기공능장애%수궤대조시험%meta분석
Tadalafil%Erectile dysfunction%Randomized controlled trial%Meta analysis
目的：对他达拉非治疗勃起功能障碍的疗效进行分析评价。方法：通过电子检索和手工检索尽可能的全面收集他达拉非治疗勃起功能障碍的临床研究的试验资料，凡属于随机对照试验，无论是否采用盲法均予纳入。以国际勃起功能指数（IIEF-5评分）以及SEP-Q2、Q3做为疗效指标，运用RevMan5.2对最终入组资料进行meta分析。结果：共7个随机对照试验被纳入研究，其中4个为Jadad评分≥4的高质量试验。3个试验IIEF-5评分分析WMD＝4.32，95％CI为[3.68，4.96]，P＜0.00001；7个试验的SEP-Q2分析，OR＝3.07，95％CI为[2.36，4.00]，P＜0.00001；4个安慰剂作为对照组的试验SEP-Q3分析，OR＝5.04，95％CI为[3.66，6.92]，P＜0.00001；3个复方玄驹作为对照组的试验SEP-Q3分析，OR＝2.11，95％CI 为[1.49，2.97]，P＜0.00001。提示他达拉非可以明显改善ED的疗效指标。结论：他达拉非可以有效提高插入成功率和性交成功率，显著改善阴茎勃起功能。
目的：對他達拉非治療勃起功能障礙的療效進行分析評價。方法：通過電子檢索和手工檢索儘可能的全麵收集他達拉非治療勃起功能障礙的臨床研究的試驗資料，凡屬于隨機對照試驗，無論是否採用盲法均予納入。以國際勃起功能指數（IIEF-5評分）以及SEP-Q2、Q3做為療效指標，運用RevMan5.2對最終入組資料進行meta分析。結果：共7箇隨機對照試驗被納入研究，其中4箇為Jadad評分≥4的高質量試驗。3箇試驗IIEF-5評分分析WMD＝4.32，95％CI為[3.68，4.96]，P＜0.00001；7箇試驗的SEP-Q2分析，OR＝3.07，95％CI為[2.36，4.00]，P＜0.00001；4箇安慰劑作為對照組的試驗SEP-Q3分析，OR＝5.04，95％CI為[3.66，6.92]，P＜0.00001；3箇複方玄駒作為對照組的試驗SEP-Q3分析，OR＝2.11，95％CI 為[1.49，2.97]，P＜0.00001。提示他達拉非可以明顯改善ED的療效指標。結論：他達拉非可以有效提高插入成功率和性交成功率，顯著改善陰莖勃起功能。
목적：대타체랍비치료발기공능장애적료효진행분석평개。방법：통과전자검색화수공검색진가능적전면수집타체랍비치료발기공능장애적림상연구적시험자료，범속우수궤대조시험，무론시부채용맹법균여납입。이국제발기공능지수（IIEF-5평분）이급SEP-Q2、Q3주위료효지표，운용RevMan5.2대최종입조자료진행meta분석。결과：공7개수궤대조시험피납입연구，기중4개위Jadad평분≥4적고질량시험。3개시험IIEF-5평분분석WMD＝4.32，95％CI위[3.68，4.96]，P＜0.00001；7개시험적SEP-Q2분석，OR＝3.07，95％CI위[2.36，4.00]，P＜0.00001；4개안위제작위대조조적시험SEP-Q3분석，OR＝5.04，95％CI위[3.66，6.92]，P＜0.00001；3개복방현구작위대조조적시험SEP-Q3분석，OR＝2.11，95％CI 위[1.49，2.97]，P＜0.00001。제시타체랍비가이명현개선ED적료효지표。결론：타체랍비가이유효제고삽입성공솔화성교성공솔，현저개선음경발기공능。
Objectives:To analyze and evaluate the efficacy of tadalafil on erectile dysfunction.Methods:The test data of tadalafil on erectile dysfunction was collected through electronic and manual searches.All the ran-domized controlled trials,regardless of the blind method,were included.With international index of erectile function (IIEF-5 score)and SEP-Q2,Q3 as curative effect index,RevMan5.2 was used to analyze the final data by meta analysis.Results:7 randomized controlled trials were included in the study,4 of which belong to the Jadad score≥4 high quality test.The results of 3 test’s IIEF-5 score analysis were WMD=4.32 and 95%CI=[3.68,4.96],P<0.00001;the results of SEP-Q2 experimental analysis of the 7 trials were OR=3.07 and 95%CI=[2.36,4.00],P<0.00001;the results of SEP-Q3 analysis of 4 placebo test group were OR=5.04 and 95%CI=[3.66,6.92],P<0.00001;the results of SEP-Q3 analysis of 3 FuFangXuanJu test group were OR=2.1 1 and 95%CI=[1 .49,2.97], P<0.00001 .The results indicated that tadalafil could significantly improve the efficacy index of ED.Conclusions:Tadalafil can effectively improve the success rate of insertion and sexual intercourse success rate,and significantly improve the erectile function of penis.
