CAJ | 학술논문

大疱性类天疱疮是一种自身免疫性疾病,目前认为与遗传、环境、感染、药物、物理等因素有关,其中遗传因素在发病中起重要作用.研究表明,HLA基因与大疱性类天疱疮相关,尤其是人类白细胞抗原Ⅱ类等位基因,在不同地域易感基因存在一致性和差异性.还有一些非HLA基因的候选基因有致病作用,包括某些细胞因子的基因多态性、免疫球蛋白重链可变区3的多态性、Km基因型和Fcγ受体多态性,对于候选基因的研究需要大量的病例和对照.
대포성류천포창시일충자신면역성질병,목전인위여유전、배경、감염、약물、물리등인소유관,기중유전인소재발병중기중요작용.연구표명,HLA기인여대포성류천포창상관,우기시인류백세포항원Ⅱ류등위기인,재불동지역역감기인존재일치성화차이성.환유일사비HLA기인적후선기인유치병작용,포괄모사세포인자적기인다태성、면역구단백중련가변구3적다태성、Km기인형화Fcγ수체다태성,대우후선기인적연구수요대량적병례화대조.
Bullous pemphigoid (BP) is an autoimmune disease associated with heredity,environment,infection,drugs,physical factors,and so on,of which,genetic factors play an important role in the pathogenesis of this autoimmune disease.It has been shown that human leukocyte antigen (HLA) loci,especially human leukocyte antigen (HLA) class Ⅱ alleles,are related to BP.Both consistency and variety exist in susceptibility genes for BP among different regions.Moreover,it is likely that non-HLA candidate genes are involved in the pathogenesis of BP,such as cytokine genes,immunoglobulin variable-region heavy chain 3 (IGHV3) genes,Km genotype,and Fc gamma receptor genes.Large-scale studies are required to investigate into these candidate genes.