决策与信息（下旬刊）
決策與信息（下旬刊）
결책여신식（하순간）
THE FRIEND OF THE HEAD
2014年
9期
108-109
,共2页
2,6-二甲基-4-碘吡啶%脱氢醋酸%合成
2,6-二甲基-4-碘吡啶%脫氫醋痠%閤成
2,6-이갑기-4-전필정%탈경작산%합성
4-iodo-2,6-dimethylpyridine%dehydroacetic acid%synthesis
以脱氢醋酸为原料经三步合成2,6-二甲基-4-碘吡啶：第一步是脱氢醋酸的亚胺化反应，第二步是2,6-二甲基-4-羟基吡啶的制备，第三步是2,6-二甲基-4-羟基吡啶的碘代反应．中间体和目标化合物的结构经MS和NMR进行了表征.本合成路线总收率92.6%，原料易得、操作简便、适合于工业化生产。
以脫氫醋痠為原料經三步閤成2,6-二甲基-4-碘吡啶：第一步是脫氫醋痠的亞胺化反應，第二步是2,6-二甲基-4-羥基吡啶的製備，第三步是2,6-二甲基-4-羥基吡啶的碘代反應．中間體和目標化閤物的結構經MS和NMR進行瞭錶徵.本閤成路線總收率92.6%，原料易得、操作簡便、適閤于工業化生產。
이탈경작산위원료경삼보합성2,6-이갑기-4-전필정：제일보시탈경작산적아알화반응，제이보시2,6-이갑기-4-간기필정적제비，제삼보시2,6-이갑기-4-간기필정적전대반응．중간체화목표화합물적결구경MS화NMR진행료표정.본합성로선총수솔92.6%，원료역득、조작간편、괄합우공업화생산。
In this paper, 4-iodo-2,6-dimethylpyridine was synthesized in a yield of 92.6% with dehydroacetic acid as material. Dehydroacetic acid reacted with aqueous ammonia giving intermediate (2), then 2,6-dimethyl-4-hydroxypyridine (3) was prepared and compound 3 was iodinated to obtain 4-iodo-2,6-dimethylpyridine (4). The target compound was characterized by MS and NMR spectra. This synthetic route has the advantages of convenient operation and mild conditions. This program is suitable for industrial production.
