CAJ | 학술논문

目的：检测凝血酶在肝细胞性肝癌（HCC）组织和癌旁组织中的表达，分析其与微血管密度（MVD）的关系，以探讨其在 HCC 发生发展中的作用。方法HCC 组织和癌旁组织42例，采用免疫组化染色法检测其凝血酶及血管内皮细胞表面抗原（CD34）表达，分析它们之间及各自与 HCC 临床病理特征之间的关系。结果HCC组织中凝血酶阳性表达率显著高于癌旁组织（P ＜0．05）；凝血酶的表达与患者术后有无复发密切相关（P ＜0．05）。凝血酶的表达与 MVD 呈正相关（P ＜0．05）。结论凝血酶在 HCC 组织中高表达并与术后复发有关，且与 MVD呈正相关，提示凝血酶可能通过促进 HCC 血管的生成从而影响 HCC 的进展及预后。
목적：검측응혈매재간세포성간암（HCC）조직화암방조직중적표체，분석기여미혈관밀도（MVD）적관계，이탐토기재 HCC 발생발전중적작용。방법HCC 조직화암방조직42례，채용면역조화염색법검측기응혈매급혈관내피세포표면항원（CD34）표체，분석타문지간급각자여 HCC 림상병리특정지간적관계。결과HCC조직중응혈매양성표체솔현저고우암방조직（P ＜0．05）；응혈매적표체여환자술후유무복발밀절상관（P ＜0．05）。응혈매적표체여 MVD 정정상관（P ＜0．05）。결론응혈매재 HCC 조직중고표체병여술후복발유관，차여 MVD정정상관，제시응혈매가능통과촉진 HCC 혈관적생성종이영향 HCC 적진전급예후。
Objective To investigate the expressions of thrombin in hepatocellular carcinoma (HCC) tissues and their neighboring noncancerous tissues ,and to analyze the relationship between thrombin expressions and microvessel density(MVD) to explore the role of thrombin in the pathogenesis and development of HCC .Methods Forty-two cases of HCC tissues and forty-two cases of neighboring noncancerous tissues were studied with immunohistochemical method in order to detect the expressions of thrombin and CD 34.Besides their correlations,their relations with clinicopathologic features of HCC were further analyzed .Results The positive rate of thrombin in HCC tissues was significantly higher than that in neighboring noncancerous tissues (P <0.05).The expression of thrombin in HCC tissues was remarkably related with postoperative recurrence (P <0.05),and positively correlated with MVD(P <0.05).Conclusion Thrombin is highly expressed in HCC tissues,related with postoperative recurrence ,and positively correlates with MVD.It suggests that thrombin might have the effects on progression and prognosis of HCC by promoting angiogenesis .